Novartis Ag

Irm LLC

Dong Han

Shifeng Pan

Wenqi Gao

Dai Cheng

Guobao Zhang

Yongqin Wan

Jiqing Jiang

Yun Feng Xie

Xu Wu

Qihui Jin

Rajender Reddy Leleti

Lichun Shen

The present invention relates to methods for modulating the Wnt signaling pathway using compounds of Formula (1), 

N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators

The present invention relates to compositions and methods for modulating the Wnt signaling pathway.

N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as WNT signaling modulators

The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).

Hedgehog pathway modulators

The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R, R, Rare as defined herein. 

Substituted pyridines for modulating the WNT signaling pathway

The present invention relates to compounds of formulae 1 and 2 and methods for modulating the Wnt signaling pathway using these compounds, wherein A, A, B, Y and Z all represent rings. 

N-(hetero)aryl, 2-(hetero)aryl&#x2014;substituted acetamides for use as Wnt signaling modulators

The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I). 

Compounds and compositions as hedgehog pathway inhibitors

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

Compounds and compositions as hedgehog pathway modulators

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I. 

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San Diego, CA, United States of America

Dong Han