Indena S.p.a.

Societa' Italiana Resine S.i.r. S.p.a.

Laboratorio Farmaceutico C.t. S.r.l.

Donato Pocar

Ezio Bombardelli

Gabriele Fontana

Maria Luisa Gelmi

Mario Brufani

Arturo Battaglia

Andrea Guerrini

Giacomo Carenzi

Riccardo Stradi

Antonella Loche

Eleonora Baldelli

Vincenzo Perlini

Giuseppe Bianchetti

A general process for the functionalization at the 14-position of 13-ketobaccatin derivatives of formula I to give derivatives of formula II wherein the substituents are as defined in the disclosure. The conversion of compounds of formula II in compounds of formula III, wherein the substituents are as defined in the disclosure, is also described. 

Taxane derivatives functionalized at the 14-position and a process for the preparation thereof

A process for the preparation of 14&#x3b2;-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity.

Process for the preparation of the 14&#x3b2;-hydroxy-baccatin III-1,14-carbonate

Thiadiazole derivatives of general formula (I) ##STR1## wherein R.sub.1 is selected from the class consisting of: C.sub.1 -C.sub.10 linear or branched alkyl, benzyl, optionally substituted at the aromatic ring with one or more groups selected on their turn from the class consisting of : C.sub.1 -C.sub.20 linear or branched alkyl residues , nitro groups, halogen atoms, C.sub.1 -C.sub.20 linear or branched alkoxy, hydroxy and C.sub.2 -C.sub.20 linear or branched acyloxy groups, R.sub.2 is selected from H, C.sub.2 -C.sub.10 alkanoyl, cycloalkanoyl wherein this ring has from 3 to 10 carbon atoms, aroyl, and R.sub.3 is selected from H and C.sub.1 -C.sub.10 alkyl, for the treatment of depressive states and anxiety, a process for their preparation and relative pharmaceutical compositions containing them as the active ingredient.

Thiadiazole derivatives for the treatment of depressive states

A novel triazole compound of the formula: ##STR1## The compound is particularly effective as pre-emergency herbicide. Dosages of 2.5 Kg/Ha to 10 Kg/Ha are recommended.

Herbicidal composition and method

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Milan, Italy

Donato Pocar