Cygnus Therapeutic Systems

Farmos Group Ltd.

Cygnus, Inc.

Donald R Wilson

Risto A Lammintausta

Gary W Cleary

Harry Gosta Jalonen

Renee A Fallon

Kenneth J Colley

Russell D Beste

Device for administering drug transdermally with a controlled temporal

A transdermal drug delivery device that administers drug in an initial pulse followed by a substantially lower continuous rate comprising a drug reservoir of the drug dissolved in a carrier and a volatile permeation enhancer confined between a backing that is permeable to the volatile permeation enhancer and an underlying substrate layer that is permeable to the drug, carrier and enhancer. When the device is placed on the skin the volatile permeation enhancer is depleted from the reservoir by evaporation through the backing such that the magnitude and duration of the pulse is dependent upon the permeability of the backing layer to the volatile enhancer.

Device for administering drug transdermally which provides an initial

Transdermal administration of dexmedetomidine, the dextrorotatory isomer of medetomidine, is described. The method involves sedating a patient by administering dexmedetomidine to a predetermined area of skin at an administration rate and for a time period effective to achieve the desired level of sedation. A therapeutic system for transdermally administering the drug is also provided. The therapeutic system is in the form of a skin patch which is a laminated composite of a backing layer, an optional anchor adhesive layer, a contact adhesive layer, and one or more additional layers.

Method and device for administering dexmedetomidine transdermally

Growing community of inventors

San Francisco, CA, United States of America

Donald R Wilson