Mallinckrodt Medical, Inc.

Other

Donald R VanDeripe

Youlin Lin

Muthanadar P Periasamy

Raghavan Rajagopalan

William P Cacheris

The disclosure details methods and gas mixtures which are useful for washing nitrogen out of the body and mitochondria following acute cerebrovascular accidents (strokes) or myocardial infarction (heart attacks) and allow the reuptake of oxygen into mitochondria of ischemic tissues following re-flow, thereby reducing the severity of reperfusion damage and cell death.

Method of use of gas mixtures to achieve nitrogen washout from the body and mitochondria of the heart

The disclosure details methods and gas mixtures which are useful for washing nitrogen out of the body and mitochondria following acute cerebrovascular accidents (strokes) and allow the reuptake of oxygen into mitochondria of ischemic tissues following re-flow, thereby reducing the severity of reperfusion damage and cell death.

Method of use of gas mixtures to achieve washout of nitrogen from the body and mitochondria

Hybrid agents for enhancing in vivo diagnostic imaging of body organs and tissues, and methods of preparing and using the same.

Iodo-phenylated chelates for magnetic resonance imaging

Iodo-phenylated chelates for x-ray contrast

The present invention relates to a system and method for oxygenation of ischemic tissue. In particular, the present invention relates to a system and method for supplying oxygen to the myocardium of the heart through means other than the coronary arteries. The system of the present invention comprises a catheter which may be used to infuse preoxygenated carrier solutions, such as perfluorocarbon emulsions, directly into the pericardial space; i.e. the space between the pericardium and the epicardial surface.

System and method for oxygenation of the pericardium

Paramagnetic chelates, as for example, Gadolinium diethylenetriaminepentaacetic acid (DTPA), manganese, ethylenediaminetetraacetic acid (EDTA), and others used as X-ray contrast agents are more toxic acutely when injected in high concentration or at rapid rates. The use of effective amounts of calcium in the form of, calcium chloride, calcium gluconate, or balanced salt solutions substantially reduces this toxicity without the need to add additional ligand.

Method for enhancing the safety of metal-ligand chelates as X-ray

A diagnostic composition suitable for administration to a warm-blooded animal, which comprises a MRI-effective amount of a zwitterionic complex of a paramagnetic ion having a cyclic or open chain structure and a pharmaceutically acceptable carrier and a method for performing a MRI diagnostic procedure using the same.

Magnetic resonance imaging agents

The present invention relates to a system and method for oxygenation of ischemic tissue. In particular, the present invention relates to a system and method for supplying oxygen to the myocardium of the heart through means other than the coronary arteries. The system of the present invention comprises a catheter which may be used to infuse preoxygenated carrier solutions, such as perfluorocarbon emulsions, directly into the pericardial space; i.e. the space between the pericardium and the epicardial surface. The preoxygenated solutions may be periodically or continuously withdrawn and fresh solutions then infused into the pericardial space.

System and method for oxygenation of the heart using subpericardial

Paramagnetic chelates, as for example, Gadolinium diethylenetriaminepentaacetic acid (DTPA), manganese, ethylenediaminetetraacetic acid (EDTA), and others used as magnetic resonance imaging contrast agents are more toxic acutely when injected in high concentration or at rapid rates. The use of effective amounts of calcium in the form of, calcium chloride, calcium gluconate, or balanced salt solutions substantially reduces this toxicity without the need to add additional ligand.

Method for enhancing the safety of metal-ligand chelates as magnetic

A pair of golf shoes, the bottom of the sole of each shoe having relatively wide flat beveled surfaces inclined inwardly and downwardly from the inner edge of the sole. These beveled surfaces allow the shoe to roll inwardly about the central longitudinal axis of the shoe when the weight of the person wearing the shoe shifts to the inner side of the foot, as during the address and backstroke stages of the golf swing. The engagement of the beveled surfaces with the ground during the swing provides the golfer with added stability.

Growing community of inventors

Lake St. Louis, MO, United States of America

Donald R VanDeripe