Stauffer Chemical Company

Zeneca Limited

Other

Edison Pharmaceuticals, Inc.

Eli Lilly and Company

Ici Americas, Inc.

Donald R James

William J Michaely

Christopher G Knudsen

Hsiao-Ling M Chin

Bing Wang

Wei Zhang

Don R Baker

Raymond A Felix

Jiangao Song

Xianfeng Li

Steven Fitzjohn

Christopher J Mathews

Gail Walkinshaw

John M Gerdes

Steven D Mielich

Jian Feng Chen

Francis H Walker

Jian Chen

Eugene G Teach

David L Lee

Sekhar S Boddupalli

Qiang Cong

Lawrence L Buren

Harry Tilles

Daniel T W Chu

Bill V Anderson

Xianming Jin

Pamela D Milano

Arkadij M Elizarov

Barney J Randolph

Donna L Lindsey

The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondria) disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

Chroman derivatives

The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful in the manufacture of pharmaceutical formulations for the treatment of lipoxygenase-mediated disorders.

Spiro derivatives as lipoxygenase inhibitors

The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

The present invention is a lounge chair that may be used by a person to comfortably lie on her back or stomach while supporting her arms and/or hands. In one embodiment, the lounge chair comprises a median member having a first end portion and a second end portion. The lounge chair further comprises a lower member and an upper member rotatably engaged with the first and second end portions of the median member, respectively. The lounge chair further comprises an arm support member rotatably engaged with the upper member. The arm support member comprises first and second arm portions disposed at opposite ends of the upper member. In operation, a person may rotate the upper member and arm support member from a first or inclined position wherein the upper member is substantially vertical to the median member and the arm support member is parallel to the median member thereby allowing a person to sit upright while comfortably supporting her arms and/or hands on the first and second arm portions to a second or flat position wherein both the upper member and the arm support member are parallel with the median member thereby allowing a person to lie on her stomach while comfortably supporting her arms and/or hands on the first and second arm portions.

Lounge chair

This invention relates to novel optionally substituted heterocyclic N-oxide compounds of formula (I): ##STR1## wherein: R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, A, X, Z and m are defined herein. In other aspects, this invention relates to herbicidal compositions containing a optionally substituted heterocyclic N-oxide compound or derivative thereof and an agriculturally acceptable carrier and to a method of controlling undesirable vegetation by applying to an area where control is desired an herbicidally effective amount of an optionally substituted heterocyclic N-oxide compound or derivative thereof.

Herbicidal heterocyclic N-oxides compounds

Substituted arylindazoles of the formula: ##STR1## wherein X is CR.sup.14 and R.sup.14 is hydrogen, halogen, haloalkyl, cyano, nitro, alkylthio, alkylsulfonyl, alkylsulfinyl or alkoxy; and substituents R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined in the specification. Use of the compounds as herbicides and methods of making the compounds are also described.

Arylindazoles and their use as herbicides

The present invention is a machine for use in attaching first and second handles to a gift box. Each of the first and second handles having first and second end portions and an upper portion. In one embodiment, the machine comprises a base member and first and second side walls extending upward therefrom. The machine further comprises first and second handle support members rotatably connected with the first and second side walls and each being adapted to retain the first and second handles, respectively. The first and second handle support members are operable from a first and normally horizontal position wherein the handles may be inserted thereon and provided with an adhesive to a second substantially vertical position wherein the handles may be attached to the gift box.

Machine for attaching handles to a gift box

This invention relates to substituted N-benzotriazoles of the formula ##STR1## in which: R.sup.1, R.sup.2, R.sup.3,R.sup.4, R.sup.5,R.sup.6, R.sup.7, X are as defined in the specification. The compounds exhibit herbicidal activity.

N-benzotriazoles

This invention relates to substituted aryl indazoles, a process for producing them and their use as herbicides. In particular this invention relates to substituted aryl indazoles of the formula ##STR1## wherein all variables are as defined in the specification.

Substituted N-benzotriazoles of the general formula ##STR1## exhibit herbicidal activity. Herbicidal compositions and related methods of using the substituted N-benzotriazoles are also disclosed.

As new compounds, acylaminoaryloxy and arylthio pyrimidines having the formula ##STR1## wherein A is oxygen or sulfur; M is CH or N; X is hydrogen, lower alkyl, halo, methoxy, alkoxy, C.sub.1 -C.sub.3 alkylthio, cyano, carbomethoxy or trifluoromethyl; ##STR2## wherein R' is C.sub.1 -C.sub.8 straight, branched-chain or halo-alkyl, aryl; and R is hydrogen, C.sub.1 -C.sub.8 straight or branched chain alkyl, C.sub.5 or C.sub.6 cycloalkyl or aryl.

Acylaminoaryloxy and arylthio pyrimidines as herbicides

Compounds having the structural formula ##STR1## wherein R.sub.1, R.sub.2 R.sub.3, R.sub.4 and R.sup.5 are the same or different and are selected from the group consisting of hydrogen, chlorine, bromine, iodine, nitro, alkyl having from 1 to 4 carbon atoms, alkoxy having from 1 to 4 carbon atoms, trifluoromethyl, trifluoromethoxy, cyano, alkylsulfonyl, and alkylthio having from 1 to 4 carbon atoms, and wherein R.sub.2 and R.sub.3 or R.sub.3 and R.sub.4 together can be methylene or ethylenedioxy.

Certain 2-(2-(substituted phenyl)acetyl)-1,3-cyclohexanediones

An intermediate compound having the structural formula ##STR1## wherein X is oxygen or sulfur;

Certain 4-oxo-3-benzoylvalerolactones and thiolactones

Compounds having the formula ##STR1## wherein X is oxygen or sulfur;

Compounds having the formula ##STR1## wherein X is sulfur;

Growing community of inventors

El Sobrante, CA, United States of America

Donald R James