St. Luke's-roosevelt Hospital

Stolle Research & Development Corporation

St. Luke's-roosevelt Hospital Center

Donald P Kotler

Emilia M Sordillo

Lee R Beck

Richard N Pierson

Jack Wang

Mary Horlick

John Thornton

Stephen M Arpadi

Creatinine clearance is estimated in a patient by determining his or her body cell mass. In turn, the body cell mass of the patient is measured using bioimpedance analysis techniques. The patient's serum creatinine concentration is also measured. The body cell mass and the serum creatinine concentration provide an indication of actual creatinine clearance in the subject through use of a predictive formula. From this prediction, accurate dosages of potentially nephrotoxic medications can be appropriately prescribed.

Method for estimating creatinine clearance in obese and malnourished

A method for predicting fat free mass (FFM) and total body water (TBW) of a prepubertal child infected with human immunodeficiency virus (HIV) comprises the steps of measuring a child's height, measuring the child's total body resistance, and predicting fat free mass (FFM) and total body weight (TBW) of said child using the measured height and total body resistance.

Method of predicting body composition in prepubertal children infected

Creatinine clearance is estimated in a patient by determining his or her body cell mass. In turn, the body cell mass of the patient is measured using bioimpedance analysis techniques. The determined value of body cell mass is normalized by the height.sup.2 of the patient. The body cell mass or its normalized value provides an indication of actual creatinine clearance in the subject through use of a predictive formula. From this prediction, accurate dosages of potentially nephrotoxic medications can be appropriately prescribed.

Method for estimating creatinine clearance using measurements of body

The inability to precisely estimate body composition using simple, inexpensive and easily applied techniques is an impediment to clinical investigations in nutrition. In this study, predictive equations for body cell mass (BCM), fat free mass (FFM), and total body water (TBW), were derived, using single frequency bioimpedance analysis (BIA), in 332 subjects, including white, black and hispanic men and women, both normal healthy controls and patients infected with the human immunodeficiency virus (HIV). Preliminary studies demonstrated more accurate predictions of BCM when using parallel transformed values of reactance than the values reported by the bioimpedance analyzer. Modeling equations derived after logarithmic transformation of height, reactance and impedance were more accurate predictors than equations using height.sup.2 /resistance, and the use of gender-specific equations further impoved accuracy. The addition of weight to the modeling equation also improved accuracy but was less important than the impedance measurements. The resulting equations were internally validated, and race, disease (HIV infection) and malnutrition were shown not to affect the predictions. The equation for FFM also was validated externally against results derived from hydrodensitometry measurements in a group of 440 healthy individuals, with a standard error of the estimate of under 5%. These results indicate that body composition can be estimated accurately using simple, inexpensive, and easily applied techniques, and that the estimates are sufficiently precise for use in clinical investigation and clinical practice.

Method of predicting body cell mass using bioimpedance analysis

The invention comprises treatment of gastrointestinal disorders of parasitic protozoan and bacterial origin in immunocompromised and immunocompetent animals by administration hyperimmune milk products.

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New Rochelle, NY, United States of America

Donald P Kotler