E.i. Dupont De Nemours and Company

Dade Behring Inc.

Dade Chemistry Systems Inc.

Donald M Simons

Susan Y Tseng

Patricia C Weber

William A Frey

David M Obzansky

This invention relates to quinidine derivatives and immunogenic conjugates and reporter conjugates prepared therefrom. The immunogenic conjugates and reporter conjugates are useful for eliciting antibodies and for performing immunoassays for quinidine. A particle agglutination immunoassay for quinidine is also provided.

Quinidine conjugates and their use in immunoassays

Avidin-binding azo reagents which alter the spectrophotometric properties of avidin and the use of such reagents in homogeneous assays are described.

Homogeneous assays using avidin-binding azo reagents

Avidin-binding fluorescing and quenching reagent for use in homogeneous

Avidin-binding azo reagents

Immunoassays and DNA probe assays utilizing a non-immune, reversible binding displacement system are provided. In the assay, a releasable ligand, a binding partner for the releasable ligand, an analyte of interest, an analytically detectable (reporter) group, and at least one binding partner for the analyte, are first attached to an insoluble phase so as to form reporter-labeled complex bound to an insoluble phase, followed by the addition of a displacer ligand which displaces the releasable ligand along with some portion of the reporter-labeled complex, so that the released reporter is analytically detectable in a free liquid medium and can be related to the concentration of analyte in the sample.

Method for specific binding assays using a releasable ligand

Estriol and estradiol glycidyl ethers, immunogenic conjugates thereof and processes for their preparation are provided. The immunogenic conjugates are useful for eliciting and purifying antibodies and in performing immunoassays for estriol and estradiol.

Estriol derivatives

Particle reagents, having polyether polyamine linking groups, for use in turbidimetric immunoassays are provided. These linking agents permit ready covalent attachment of compounds of biological interest to polymer particles and lead to immunoassays of improved precision.

Polyether polyamines as linking agents for particle reagents useful in

Certain filled propylene polymer compositions, especially propylene homopolymers filled with a carbon black (10-50 parts per 100 parts of polymer) and containing about 30-50 parts of intumescent fire-retardant obtained by heating a mixture of a polyol, a phosphorus acid, and melamine have very high ignition resistance and desirable physical properties. When usual inorganic fillers are used, instead of carbon black, good ignition resistance is not obtained. Carbonaceous materials other than carbon blacks, for example, acetylene blacks, graphite, and so-called Austin black reduce or completely counteract the fire-retardant activity of the intumescent fire retardant. Filled propylene polymer compositions of this invention are particularly suitable in applications where the fire hazard is particularly great, for example, in automotive parts under the hood and in electrical applications.

Flame retardant filled polypropylene compositions containing carbon

Polypropylene compositions having high ignition resistance, flex modulus, and impact resistance are obtained by blending polypropylene homopolymer, a propylene/ethylene copolymer, an EPM or EPDM elastomer having an ethylene content of about 50-65 weight percent and a Mooney viscosity of 35-80, mica, a commercial chlorinated fire retardant, and antimony trioxide in defined proportions. These compositions are particularly suitable for electrical wire insulation and other applications where toughness, stiffness, and ignition resistance are important.

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Wilmington, DE, United States of America

Donald M Simons