Warner-Lambert Company

Donald M Lynch

Benjamin Appelbaum

Mamoun M Hussein

Lori D Kumar

Shirley A Barcelon

Pauline H Pan

Steven S Dills

Compositions having improved anti-plaque and anti-gingivitis activity comprise a synergistic combination of a) a morpholinoamino alcohol or salt thereof, such as 3-(4- propylheptyl)-4-(2-hydroxyethyl) morpholine, and b) a metal salt, such as the salts of divalent zinc, copper and magnesium.

Anti-plaque compositions comprising a combination of morpholinoamino

The combination of pepper-like constituents, such as piperine, and volatile formate esters, such as ethyl formate, is useful as a substitute for chloroform in pharmaceutical, oral hygiene and confectionery compositions.

Combination of formate esters and pepper-like constituents as an

The invention provides plaque-inhibitory agents useful in oral compositions such as mouthwashes, toothpastes, mouthrinses, dental creams, toothpowders etc. comprising polysaccharides such as xanthan gum, gum tragacanth (pectin), guar gum, gum karaya, chondroitin sulfate, polygalacturonic acid, sodium alginate and carrageenans of the kappa/lambda configuration. The agents are effective in plaque-inhibiting at concentrations between about 0.0025% and 2.000% on a weight/volume basis.

Saccharide inhibition of dental plaque

The invention provides an oral preparation or composition such as a mouthwash, mouthrinse, toothpaste and the like containing certain classes of surfactants which act to inhibit plaque formation by inhibiting the initial adherence of bacteria to the dentin surfaces and in the case of one class of surfactants additionally inhibiting the glucosyl transferase catalysis to prevent the synthesis of extracellular polysaccharides from sucrose. The surfactants comprise substituted taurines, substituted isethionates and substituted hydroxy sultaines in which the substituents are long chain hydrocarbon radicals. The surfactants are employed in the aqueous-based oral compositions at concentrations between about 0.00001M to 0.1M to effect inhibition.

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Flemington, NJ, United States of America

Donald M Lynch