Lexmark International, Inc.

Washington University

Eidgenossische Technische Hochschule Zurich

The University of Texas System

Unversität Zürich

California Institute of Technology

Other

International Business Machines Corporation

Univesitat Zurich

Genzyme Corporation

Donald Leo Elbert

Jeffrey Alan Hubbell

Bradley Leonard Beach

Ronald Schoenmakers

Amarpreet S Sawhney

Terence E Franey

Eric Leuthardt

David A Melanson

Paul D Drumheller

Ashok Murthy

Ajay Kanubhai Suthar

Kevin Dean Schoedinger

Jerry Wayne Smith

Luis Z Avila

Arthur J Coury

Shikha P Barman

Ronald Lloyd Roe

James F Feeman

Colin Derdeyn

Alan Stirling Campbell

Cory Nathan Hammond

George E Selecman

Stephen D Goodrich

Ronald S Rudowsky

Jennifer L Hill-West

Richard B Watkins

John Melvin Olson

Guy M Genin

Mark T Kieras

Sean David Smith

Philip V Bayly

Dean M Pichon

Claudia Alexandra Marin

Stacy Marie Pargett

Kathryn Dowlen Mullins

Michelle Kathryn Morris

Johnathan Lee Barnes

Curtis B Herbert

Robert L Vollmer

Bradley C Poff

David J Nedder

Sanghamitra Chowdhury

Natalie D Winblade

Benjamin John Goebel

John C Spiridigliozzi

Richard W Holt

Jacob Roam

Evan A Scott

Carla M Butler

Rodney O Aulick

Eric L Ziercher

Thomas S Bromander

Nicola Tirelli

Chandrashekar P Pathak

William Hargis Barton

Robert Glenn Smith

Jeffrey A Hubbell

Chandu Vemuri

Kenneth E Edds

Brent Vernon

Allen C Sanders

Michael D Nichols

Marc A Levine

William C McCornack

Matthias Lütolf

Shannon Alford

Greg Zipfel

William D Bailey

Paul D Drumbeller

Katie McCoy

Junwoo Suh

Yuni Teh

Alan Zhao

Alison Pratt

Megan Kaneda

Brad Wacker

Jeffrey A Hubbel

Douglas JK Weaver

Curtis B University Of Minnesota Herbert

A stent for placement in a blood vessel with a wall having an aneurysm including an endovascular graft having a first end, a second end, and a tubular body that is expandable and extends from the first end to the second end. The stent also includes a coagulation apparatus attached to the tubular body between the first and second ends. The coagulation apparatus has a frame and a coagulant attached to the frame. When the stent is deployed within the blood vessel, the tubular body extends across the aneurysm and expands at the first and second ends to seal against the wall of the blood vessel such that blood is channeled across the aneurysm through the tubular body such that a pocket of blood is defined external to the tubular body. The frame expands into the pocket to orient the coagulant therein and promote coagulation of blood within the pocket.

Device and method of inhibiting endoleaks

Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof.

Hydrogel microparticle scaffold with gradients of degradability and methods thereof

The invention generally relates to substrates and surfaces having substrates. Generally speaking, the substrates may be thinly layered substrates, and the surfaces may comprise thinly layered substrates. Additionally, the substrates may comprise a multifunctional water soluble polymer and a lipoprotein and the surfaces may comprise a multifunctional water soluble polymer and a lipoprotein.

Biomaterials having nanoscale layers and coatings

The field of the disclosure relates to microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof. Further, the field of the disclosure relates to coatings and scaffolds comprising microparticles and the processes for forming thereof.

Hydrogel microparticle formation in aqueous solvent for biomedical applications

The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.

Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups

The present invention is generally directed to composite materials or charge rolls comprising a sleeved foam charge roll where the sleeve is interference-fit over the foam core, and methods of constructing them. The foam core can be made with an outer diameter larger than that of the sleeve inner diameter. The sleeve can be interference fit over the foam core to provide a functional charge roll. In some embodiments the charge roll can be used in an image forming apparatus including, but not limited to, an electrophotography system, an electrophotographic copying machine, and a laser printer.

Interference fit sleeved foam charge rolls and composite materials

Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds

Compositions for coating biological and non-biological surfaces, which minimize or prevent cell-cell contact and tissue adhesion, and methods of preparation and use thereof, are disclosed. Embodiments include polyethylene glycol/polylysine (PEG/PLL) block or comb-type copolymers with high molecular weight PLL (greater than 1000, more preferably greater than 100,000); PEG/PLL copolymers in which the PLL is a dendrimer which is attached to one end of the PEG; and multilayer compositions including alternating layers of polycationic and polyanionic materials. The multi-layer polymeric material is formed by the ionic interactions of a polycation and a polyanion. The molecular weights of the individual materials are selected such that the PEG portion of the copolymer inhibits cellular interactions, and the PLL portion adheres well to tissues. The compositions and methods are useful, for example, in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells. The compositions and methods are also useful for coating non-biological surfaces such as metallic surfaces.

Multifunctional polymeric tissue coatings

The invention discloses materials that adsorb readily to the surfaces of body tissues in situ and provide a steric barrier between such tissues, so that tissue adhesions, which typically form following surgical procedures, are minimized. These materials contain a polymer of hydrophilic molecules such as polyethylene glycol (PEG) bound to a polymer that spontaneously adsorbs to biological tissue such as phenylboronic acid (PBA). The PEG-PBA co-polymer can be formed in a variety of geometries. The materials can also be used to coat prosthetics and other implants.

Methods and compositions to prevent formation of adhesions in biological tissues

A drive roller having a polyurethane coating that has a coefficient of friction with respect to a belt effective to drive the belt over the operative life of the belt. The drive roller may be included in an image-forming device to drive a belt.

Polyurethane coatings and drive rollers including the same

A roll comprising polymeric foam having a density of at least about 6 pounds per cubic foot and a compression force deflection of at least about 2.5 pounds per square inch. The roll may be used in image forming devices, and may be specifically employed as a toner added roll in electrophotographic image forming devices for toner applications.

High density foam roll

Growing community of inventors

Lexington, KY, United States of America

Donald Leo Elbert