Bayer Cropscience Gmbh

Teijin Pharma Limited

Donald James Simpson

Dale Mitchell

Hiroaki Makino

Kenichiro Kataoka

John Atherall

Gen Unoki

Minoru Imai

Tomomi Kosugi

Thomas Lawley Hough

Yuko Yamakoshi

Mika Takakuwa

Joelle Le

Clifford John Harris

Mark David Charles

Wilfried Franke

David Eric Green

The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent MAPKAP-K2 inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for MAPKAP-K2 mediated disorder, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth. 

Pyrazolo[1,5-a]pyrimidine derivatives

The invention provides fungicidal compounds of formula (I) and salts thereof wherein: Ris alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; Rand R, which may be the same or different, are any group defined for R; cyano; acyl; &#x2014;ORor &#x2014;SR, where Ris alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted; or Rand R, or Rand R, together with their interconnecting atoms may form a ring, which may be substituted; Ris alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted; hydroxy; mercapto; azido; nitro; halogen; cyano; acyl; optionally substituted amino; cyanato; thiocyanato; &#x2014;SF; &#x2014;OR; &#x2014;SRor &#x2014;Si(R); m is 0 to 3; when present R, which may be the same or different to any other R, is any group defined for R; Ris optionally substituted carbo- or heterocylclyl; and A is a defined linking group, or &#x2014;A&#x2014;Rand Rtogether with benzene ring M form an optionally substituted fused ring system.

N2-phenylamidine derivatives

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Essex, United Kingdom

Donald James Simpson