Shire Laboratories, Inc.

Middlebrook Pharmaceuticals, Inc.

Shire Llc, USA

Donald J Treacy

Edward M Rudnic

Beth A Burnside

Rong-Kun Chang

Richard Alan Couch

Xiaodi Guo

Charlotte M McGuinness

Kimberly Fiske

Sandra E Wassink

James D Isbister

Charlotte M McGuiness

A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising an immediate-release component and an enteric delayed-release component wherein (1) the enteric release coating has a defined minimum thickness and/or (2) there is a protective layer between the pharmaceutically active amphetamine salt and the enteric release coating and/or (3) there is a protective layer over the enteric release coating. The product can be composed of either one of a number of beads in a dosage form, including either capsule, tablet, or sachet method for administering the beads.

Oral pulsed dose drug delivery system

A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising an immediate-release component and an enteric delayed-release component wherein (1) the enteric release coating has a defined minimum thickness and/or (2) there is a protective layer between the pharmaceutically active amphetamine salt and the enteric release coating and/or (3) there is a protective layer over the enteric release coating. The product can be composed of either one or a number of beads in a dosage form, including either capsule, tablet, or sachet method for administering the beads.

An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cfor the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more delayed release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cat different times.

Antiviral product, use and formulation thereof

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Woodbine, MD, United States of America

Donald J Treacy