Thermedics Inc.

Other

Beth Israel Deaconess Medical Center, Inc.

Critikon, Inc

University of Rhode Island

Biomod Surfaces

Donald J Dempsey

Michael Szycher

Jonathan L Rolfe

Matthew D Phaneuf

William C Quist

Frank W Logerfo

Martin J Bide

Frank W LoGerfo

Ronald E Cambron

Hartley A Silverwood

Kevin M Mills

The invention features a method of treating polyester material to generate functional carboxylic acid and amine groups. These functional groups can be used as sites for covalent bond formation to attach chemical or biological moieties. This bifunctionalized polyester polymer can be used in any medical application in which biocompatible polymers are used.

Bifunctionalized polyester material for surface treatment and biomodification

Provided is a biocompatible device which has been coated or sealed with a polyether or polyether/carbonate based urethane polymer that contains functional groups (e.g. carboxylic acid groups) which are capable of serving as anchor sites for protein binding.

Polyurethane-sealed biocompatible device and method for its preparation

Catheters formed from polyurethanes containing sufficient halogenated moieties in the polymer structure to make the polyurethanes radiopaque are disclosed. Such polyurethanes can be prepared by employing halogenated diols and/or halogenated diisocyanate reactants. In preferred cases, the catheters are optically transparent in addition to being radiopaque.

Radiopaque polyurethanes and catheters formed therefrom

A drug releasing system in the form of a medical patch comprised of a drug dispensing polyurethane member as a matrix for a therapeutically effective amount of drug dispersed therein. The polyurethane of the drug dispensing or releasing member is a polyurethane acrylic copolymer which is the reaction product of an oligomer of a diisocyanate, a glycol with a molecular weight between the range of 500-5,000 molecular weight units and an acrylyl chain terminator having a molecular weight between the range of 40-200 molecular weight units cured by actinic radiation. In its preferred embodiment, the foregoing drug releasing or dispensing member is incorporated into a medical patch or drug release system comprised of successive layers of an ultrathin polyurethane substrate, pressure sensitive adhesive, the above-described drug releasing member and optionally a second layer of adhesive. The drug release system of the present invention is biocompatible, oxygen and water vapor permeable, flexible and can incorporate a wide variety of drugs for a controlled, sustained release to the wearer.

Drug release system

The disclosed wound dressings have a drug dispersed throughout a polyurethane matrix that is the reaction product of: (A) An isocyante terminated prepolymer formed by reaction of isophorone diisocyanate and a macroglycol and (B) a monomer containing hydroxyl and vinyl groups. The reaction product is a vinyl terminated polyurethane oligomer which is liquid at room temperature and which may be readily admixed with a pharmacoactive substance and a photosensitizer, formed into a film and cured by exposure to UV light without release of heat. In the most preferred embodiments the foregoing oligomer is codissolved in an organic solvent with a polyurethane polymer which is the reaction product of:

Drug dispensing wound dressing

The actinic radiation cured composition of this invention comprises a polyurethane acrylic copolymer containing a light scattering or fluorescing material. The polyurethane acrylic copolymer is fully cured and is flexible and elastomeric.

Growing community of inventors

Newbury, MA, United States of America

Donald J Dempsey