Vilnius University

Eth 7lirich

Eth Zërich

Eth Zurich

Donald Hilvert

Linas Mazutis

Arvydas Janulaitis

Greta Stonyte

Vaidotas Kiseliovas

Rapolas Zilionis

Robertas Galinis

Sabine Studer

Thomas George Watt Edwardson

Thomas Edwardson

The present invention relates to polypeptides self-assembling into nanoparticles. In particular, the invention relates to a polypeptide comprising an amino acid sequence I (SEQ ID NO: 1), a nucleic acid sequence encoding said polypeptide, a nanoparticle comprising at least one polypeptide of the invention, a complex comprising said nanoparticle and one or more cargo molecules, and a method for transfecting a cell with said complex.

Polypeptides self-assembling into nanoparticles

Disclosed is a system and method for production of DNA particles and use thereof. The DNA particles can be produced by amplification of nucleic acid molecule(s). Alternatively, DNA particles can be prepared by condensing multiple DNA molecules. The DNA condensation into a particle is mainly triggered by pyrophosphate and positively charged cations (e.g. magnesium). DNA particles can be applied for numerous biological applications but not limited to directed evolution, proteomics, drug delivery and imaging. DNA particles can be used to synthesize proteins using in vitro transcription/translation reaction.

System and method for synthesis of DNA particles and use thereof

Growing community of inventors

Zürich, Switzerland

Donald Hilvert