Allelix Biopharmaceuticals Inc.

Nps Allelix Corporation

Nps Pharmaceuticals, Inc.

Donald G Munroe

Tejal B Vyas

Ashwani K Gupta

Kirk McCallum

Rajender Kamboj

Diana Peters

Ermei Fan

Roman L Zastawny

Fatemeh Kooshesh

Fatemch Kooshesh

Jerold J Chun

Ermi Fan

Kirk Mccallum

The invention relates to nucleotides and amino acid sequences encoding Glucagon-like peptide-2 receptors, recombinant host cells transformed with such nucleotides, and methods of using the same in drug screening and related applications.

Cloned glucagon-like peptide-2 receptors

The invention relates to nucleotides and amino acid sequences encoding glucagon-like peptide 2 receptors, recombinant host cells transformed with such nucleotides, and methods of using the same in drug screening and related applications.

A novel, isolated EDG receptor that upon activation results in increased induction of IL-8 or NF-&#x3ba;B. Preferably, the EDG receptor is a human EDG-4 receptor, which has an amino acid sequence shown in FIGS.A andB, or a variant of these sequences having at least 91% sequence identity.

Isolated human EDG-4 receptor

The present invention is directed to nucleic acid sequence and amino acid sequences for mammalian EDG-7 receptor homologs, and particularly for human EDG-7 receptor homologs. The invention also provides methods for determining agonists and antagonsits for EDG-7 receptors in addition to assays, expression vectors, host cells and methods for treating disorders associated with abherrent expression or activity of EDG-7.

Mammalian EDG-7 receptor homologs

A lysolipid receptor, a human EDG-4 receptor, a method of identifying lysolipid receptors involved in inflammatory response and the lysolipid receptors so identified, and a method of identifying ligands which interact with such lysolipid receptors.

Isolated human EDG-4 receptor and polynucletide encoding said receptor

Cloned glucagon-like peptide 2 receptors

The present invention describes a nucleic acid sequence and an amino acid sequence for novel mammalian, including human, EDG-5 receptor homologs.

Mammalian EDG-5 receptor homologs

The present invention is directed to an isolated polynucleotide for novel G-Protein Coupled Receptors. More particularly, the present invention provides an isolated polynucleotide comprising the nucleic acid sequence SEQ ID NO: 1 or nucleic acid sequences that hybridize to SEQ ID NO: 1 or its complimentary strand having at least 40% sequence identity. Preferably, the hybridizing nucleic acid sequence should hybridize under stringent conditions and in particular have 85% sequence identity, more preferably 90% sequence identity, and most preferably 95% sequence identity.

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Waterdown, Canada

Donald G Munroe