Bristol-Myers Squibb Compnay

Bristol-Myers Squibb

Donald G Jackson

Liana M Lee

John N Feder

Chandra S Ramanathan

Suzanne J Suchard

Thomas C Nelson

Matthew V Lorenzi

Joshua N Finger

Nathan O Siemers

C Gordon Todderud

Dana Banas

Stanley Richard Krystek, Jr

Ricardo Attar

Marco Gottardis

Gena S Whitney

Rolf-Peter Ryseck

Donna A Bassolino

The invention relates to the identification and cloning of a two novel full-length human SLAP-2 variants and their encoded polypeptides, hSLAP-2v3 and hSLAP-2v4. hSLAP-2v3 and hSLAP-2v4 are members of the SLAP family of adapter proteins and are involved in the negative regulation of intracellular T-cell signal transduction. The invention further relates to the use of these novel hSLAP-2v3 and hSLAP-2v4 polynucleotides and their encoded polypeptides as targets for therapeutic intervention in immunological and inflammatory disorders, autoimmune diseases, pulmonary diseases, proliferative immune disorders, and cancer.

Polynucleotides encoding human SLAP-2 variant, hSLAP-2v3

The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.

Human histone deacetylase, HDAC9c

The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

Human phosphatase RET31, and variants thereof

Polynucleotides encoding human histone deacetylase HDAC9c

Polynucleotides encoding the novel human phosphatase, RET31, and variants thereof

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Lawrenceville, NJ, United States of America

Donald G Jackson