Light Age, Inc.

Allied Corporation

Other

Alliedsignal Inc.

Berry, Michael

Heller, Donald F.

Serdarevic, Olivia

Donald F Heller

Jerzy S Krasinski

Timothy C Chin

Olivia N Serdarevic

Michael Vance Berry

Chunbai Wu

John C Walling

Brian Pryor

Robert C Morris

Paul A Papanestor

Yehuda B Band

Marc Klosner

Thangavel Thevar

Bruce Boczar

Oded Kafri

Ralf Engelhardt

Sam A Tuccio

Margaret N Long

Ralf Brinkmann

Jui T Lin

Mahendrakumar G Jani

Richard C Powell

Jay R Ackerhalt

Burton E Sarnoff

Michael Berry

Olivia Serdarevic

In some embodiments, the instant invention includes a laser device that includes: a laser generating module that produces a plurality of laser pulses having a time-stricture pulse format that includes at least: a plurality of micropulses, a macropulse time envelope, where the plurality of micropulses are within the macropulse time envelope; where the time-stricture pulse format is configured so that the laser device is capable of treating human tissue by selectively targeting or affecting at least one first tissue or at least one first disease organisms while not substantially affecting at least one first surrounding or adjacent tissue.

Laser devices generating time structured laser pulses for selective targeting of tissues and uses thereof

In some embodiments, the instant invention provides for a system that includes at least the following components: (i) an Alexandrite laser pumping subsystem; where the Alexandrite laser pumping subsystem is configured to: 1) produce wavelengths between 700 and 820 nm, and 2) produce a pump pulse having: i) a duration between 1 to 10 milliseconds, and ii) an energy measuring up to 100 Joules; where the Alexandrite laser pumping subsystem includes: 1) an optical fiber, and 2) a Lens system, (ii) a Thulium doped Yttrium Aluminum Garnet (Tm:YAG) laser subsystem; where the Tm:YAG laser subsystem includes: 1) a Tm:YAG gain medium, 2) a rod heat sink, and 3) at least one cooling device, (iii) a wavelength selecting device, where the wavelength selecting device is configured to deliver a wavelength between 1.75 microns to 2.1 microns; and where the system is configured to produce a high energy conversion efficiency.

Laser devices utilizing alexandrite laser operating at or near its gain peak as shorter-wavelength pumping sources and methods of use thereof

The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased eletastic modulus; methods for producing and using the new composition of matter for modifying cortical structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.

Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof

The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.

The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.

In one embodiment, the instant invention provides a method that includes: outputting a first laser beam having: a beam quality factor (M2) between 1 and 5, and a spectral width of less than 0.15 nm, where the outputting is performed by a laser generating component that includes a alexandrite laser oscillator; converting the first laser beam through a first Raman cell to produce a second laser beam, where the first Raman cell is filled with a first gas; and converting the second laser beam through a second Raman cell to produce a final laser beam, where the second Raman cell is filled with a second gas and is operationally positioned after the first Raman cell, where the first gas and the second gas are different gasses, and where the final laser beam having: a second energy of at least 1 mJ, and at least one wavelength longer than 2.5 micron.

Raman converting laser systems

In one embodiment, the instant invention is an optical structure that includes: an optical active medium of a solid state laser, where the optical active medium has a first coefficient of thermal expansion; and a protective structure that is directly cladded a portion of the optical active medium, where the protective structure has a second coefficient of thermal expansion which matches the first coefficient of thermal expansion of the optical active medium, and where the protective structure is transparent to a wavelength that is within an absorption band of the optical active medium so that the optical structure has: the optical active medium that is protected from a physical damage, and the optical active medium that is capable of generating a laser beam having a first energy that is larger than a second energy generated by a control optical structure having the optical active medium without the protective structure.

Methods for manufacturing and using solid state laser systems having cladded lasing materials

In one embodiment, the instant invention provides a method that includes: outputting a first laser beam having: a beam quality factor (M) between 1 and 5, and a spectral width of less than 0.15 nm, where the outputting is performed by a laser generating component that includes a alexandrite laser oscillator; converting the first laser beam through a first Raman cell to produce a second laser beam, where the first Raman cell is filled with a first gas; and converting the second laser beam through a second Raman cell to produce a final laser beam, where the second Raman cell is filled with a second gas and is operationally positioned after the first Raman cell, where the first gas and the second gas are different gasses, and where the final laser beam having: a second energy of at least 1 mJ, and at least one wavelength longer than 2.5 micron.

A tunable solid-state laser system whose bandwidth and wavelength are controlled by the injection of light from a semiconductor diode laser. This laser system is capable of providing output light pulses over substantially all wavelength ranges in the electromagnetic spectrum. When suitably configured, it creates wavelength tunable (or fixed wavelength) pulses having spectral bandwidths that are Fourier transform limited and wavelength stabilized. The coupling means between the semiconductor diode laser and the ring laser cavity incorporates a means for optically isolating the diode laser source from optical feedback from the ring laser, ensuring diode laser source stability.

Narrow spectral bandwidth tunable pulsed solid-state laser system

The present invention encompasses an apparatus for pumping a laser (vibronic or otherwise), which comprises: a transition-metal ion-containing solid state laser gain medium; a means for exciting said laser medium to emit coherent radiation said exciting means being a pumping source comprising at least one laser diode operating at a wavelength shorter than 800 nm; and an optical resonator means for generating and controlling said coherent radiation. The present invention also encompasses a method of pumping a laser (vibronic or otherwise) comprising the steps of: generating a laser diode pumping beam at a wavelength shorter than 800 nm; exciting a transition-metal ion-containing solid state laser gain medium by impinging said laser diode pumping beam on said transition-metal ion-containing solid state laser gain medium, so as to excite the laser medium; and an optical resonator to emit coherent radiation.

Method and apparatus for pumping of transition metal ion containing

Tunable optical parametric amplifiers and oscillators that are pumped by the light from a tunable laser source are disclosed. One possible embodiment uses a tunable solid-state laser pump and an OPA medium or nonlinear crystal, such as potassium titanyl phosphate KTP or barium borate BBO or lithium borate LBO. The second harmonic output from a tunable solid-state laser is also used to pump the OPA medium. A singly or doubly resonant cavity design is preferably used to reduce the oscillation threshold (i.e., the required pump beam power) of the OPO.

Optical parametric amplifiers and oscillators pumped by tunable laser

A method of laser lithotripsy is disclosed that utilizes pulse stretched Q-switched solid state lasers in conjunction with relatively small diameter optical fibers to achieve effective breakup of calculi located within the body, such as kidney and gall stones.

Pulse stretched solid-state laser lithotripter

The present invention encompasses an apparatus for pumping a vibronic laser, which comprises: a transition-metal ion-containing solid state vibronic laser gain medium; a means for exciting said laser medium to emit coherent radiation said exciting means being a pumping source comprising at least one laser diode operating at a wavelength shorter than 750 nm; and an optical resonator means for generating and controlling said coherent radiation. The present invention also encompasses a method of pumping a vibronic laser comprising the steps of: generating a laser diode pumping beam at a wavelength shorter than 750 nm; exciting a transition-metal ion-containing solid state vibronic laser gain medium by impinging said laser diode pumping beam on said transition-metal ion-containing solid state laser gain medium, so as to excite the laser medium; and an optical resonator to emit coherent radiation.

Growing community of inventors

Somerset, NJ, United States of America

Donald F Heller