Dana-Farber-Cancer Institute Inc.

Center for Blood Research, Inc.

Donald E Staunton

Timothy Alan Springer

Michael L Dustin

Michael S Diamond

The invention concerns the use of functional derivatives of ICAM-1 to treat viral infection. The invention also provides a vaccine to prevent such infection, and a diagnostic assay to determine the existence and extent of such infection.

Functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy

Use of functional derivatives of the intercellular adhesion molecule ICAM-1 in diagnosis of viral infection

The present invention relates to intercellular adhesion molecules (ICAM-2) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.

Intercellular adhesion molecule&mdash;2 and its binding ligands

Pharmaceutical composition of the intercellular adhesion molecule ICAM-1 for use in anti-viral prophylactic therapy

Antibodies to ICAM-2, and fragments thereof

Purified ICAM-2 and fragment thereof

Isolated nucleic acid molecules encoding ICAM-2

Functional derivatives of ICAM-1 which are substantially capable of

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Chestnut Hill, MA, United States of America

Donald E Staunton