The UAB Research Foundation (the University of Alabama at Birmingham)

Other

Donald D Muccio

Wayne J Brouillette

Venkatram Reddy Atigadda

Lawrence James DeLucas

Christie G Brouillette

Laurent Schmitt

Mark J Jedrzejas

John M Ruppert

Yancho Devedjiev

Jose Gabriel Garcia

Walter Cristofoli

Sadanandan Velu

Jeonga Kim

Susan M Ruppert

Sadanadan E Velu

Clinton J Grubbs

Susan M Lobo Ruppert

Novel rexinoid compounds are provided herein. Also provided herein are methods of using the compounds to treat disorders, such as metabolic disorders, diabetes, insulin resistance, glucose intolerance, obesity, steatosis, inflammation, and/or cancer.

Rexinoid compounds and methods of using rexinoid compounds for treating metabolic disorders and cancer

Described herein are methods for making retinoids. Also described herein are retinoids and methods of use thereof.

Methods for making retinoids and uses thereof

The present invention provides new retinoid compounds and uses of the compounds in humans and animals for non-neoplastic dermal or inflammatory conditions or disorders.

Retinoids and use thereof

The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial NAD synthetase enzyme.

Inhibitors of bacterial NAD synthetase

The present invention provides new retinoid compounds and uses of the compounds in humans and animals for chemoprevention of skin and/or breast cancer and for therapy of leukemia.

Retinoid compounds with bioactive properties and their synthesis are described. The compounds are useful as chemopreventive or cancer-treating agents and dermatological agents. The novel retinoids are members of either of the two general structures: ##STR1## wherein X is CO.sub.2 H or CH.sub.2 OH; and in formula (I), R.sub.1 and R.sub.2 are each hydrogen, a C.sub.1-4 alkyl, a C.sub.1-4 alkoxy, or R.sub.1 and R.sub.2 taken together form a 5- to 7-membered cycloalkyl or cycloalkenyl ring; and in formula (II), R.sub.1 and R.sub.2 are each hydrogen, a C.sub.1-4 alkyl, a C.sub.1-4 alkenyl or a C.sub.1-4 alkoxy, or R.sub.2 and R.sub.3 taken together form a 5- to 7-membered cycloalkyl or cycloalkenyl with R.sub.1 and R.sub.4 being a hydrogen atom, a C.sub.1-4 alkyl, a C.sub.1-4 alkenyl or a C.sub.1-4 alkoxy.

Retinoid compounds

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Hoover, AL, United States of America

Donald D Muccio