Minnesota Mining and Manufacturing Company

Riker Laboratories Inc.

Donald C Kvam

Joseph Kenneth Harrington

Arthur Mendel

Jerry E Robertson

Trifluoromethanesulfonamide and salts thereof are active as antiglaucoma agent and may be administered topically to the eye. Pharmaceutical formulations of such compounds are also described.

Anti-glaucoma use of trifluoromethanesulfonamide

N-Substituted perfluoroalkanesulfonamides of the formula: ##STR1## WHEREIN R.sub.f is a perfluoroalkyl group containing one to four carbon atoms, each Y is a non-cyclic group which can contain only carbon, hydrogen, oxygen, sulfur, nitrogen and halogen and m is 1-5, provided that all of the Y groups together contain not more than about twenty carbon atoms and that at least one of the Y groups contains a heteroatom selected from oxygen, sulfur, nitrogen and halogen. Also included are salts of these compounds, compositions containing the compounds of the present invention and processes for their preparation and use. The compounds are active as herbicides and plant growth modifiers.

Stunting plant growth with N-substituted perfluoroalkanesulfonamides

N-Substituted perfluoroalkanesulfonamides of the formula: ##STR1## WHEREIN R.sub.f is perfluoroalkyl group containing one to four carbon atoms, each Y is a non-cyclic group which can contain only carbon, hydrogen, oxygen, sulfur, nitrogen and halogen and m is 1-5, provided that all of the Y groups together contain not more than about twenty carbon atoms and that at least one of the Y groups contains a heteroatom selected from oxygen, sulfur, nitrogen and halogen. Also included are salts of these compounds, compositions containing the compounds of the present invention and processes for their preparation and use. The compounds are active as herbicides and plant growth modifiers.

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North Oaks, MN, United States of America

Donald C Kvam