Pharmacia & Upjohn Company

The Upjohn Co.

Other

Donald Bainbridge Carter

Tiziano Bandiera

Steven Paul Tanis

Jacqueline Lansen

Alfredo Giuseppe Tomasselli

Allen Edwin Buhl

Geri A Sawada

James H Melby

Thomas J Raub

Luisa Savini

Robert N McEwan

Gregory J Fici

Cesare Pellerano

The present invention provides mutant presenilin 1 and presenilin 2 polpeptides and polynucleotides encoding the polypeptides and methods for their production by recombinant and PCR techniques are disclosed. Methods for utilizing the mutant polypeptides in screens for inhibitors of activity are also disclosed.

Mutant presenilin 1 polypeptides

The invention provides methods for diagnosing and treating amyloid-related conditions and compounds useful for the same. The invention provides for detecting, imaging, monitoring, diagnosing, and treating conditions characterized by the binding or aggregation of amyloid fibrils. More particularly, the invention relates to using quinolinehydrazone compounds for diagnosing and treating amyloidotic conditions and also as an antioxidant.

Compounds and methods for diagnosing and treating amyloid-related conditions

Adapter for installing deep-well submersible pump with a motor in casings with inflatable seal means comprising an annular inflatable tubular bladder with pipe flow-through means, communicating with the pump; adapter and pump suspended by cable means and air pressure line means, communicating with bladder so that it can contact the cylindrical casing; and with electric cable power means communicating with pump motor and with guide wheels to negotiate curves and reduce friction on sloping casings.

Pump-in-pipe

The imidazo�1,5-a!quinolines (I) are useful in treating neurological diseases/conditions or chronic neurodegenerative diseases/conditions.

Use of imidazo�1,5-a!quinolones as neuroprotective agents

A stable transformed HEK 293 cell comprising a functional GABA.sub.A receptor that comprises a GABA.sub.A receptor .alpha. subunit, a GABA.sub.A receptor .beta. subunit and a GABA.sub.A receptor .gamma. subunit is disclosed.

Transformed cells comprising GABA.sub.A receptors

Provided are hybridomas for producing monoclonal antibodies against human prostate secretory protein (PSP15), anti-PSP15 monoclonal antibodies, fragments and derivatives thereof, and methods for their use. The antibodies are monospecific, bind to protein A and are of the IgM class of immunoglobulins. The monoclonal antibodies are useful as basic diagnostics for detecting human prostate cancer cells.

Growing community of inventors

Kalamazoo, MI, United States of America

Donald Bainbridge Carter