Bioquiddity, Inc.

Covalent Partners LLC

Other

Bioq Pharma Inc.

Donald B Bivin

Joshua W Kriesel

Marshall S Kriesel

Alan D Langerud

Thomas H Smith

Martin Stuart Edelstein

Timothy B Karpishin

Grant Merrill

Jeffery A Whiteford

Serena Joshi

Robert T Jonas

Mark Micklatcher

Phillip C Trenholme

Richard P Watts

Ralph I McNall, Iii

Thomas T Donze

George N Glavee

David J Olson

Jeremy J Harris

Josh Kriesel

A dispensing device and the method of making same for dispensing medicaments to a patient that includes a housing, a first assembly connected to the first end of the housing that includes a body portion, and a penetrating sub-assembly. The first assembly also includes a rate control chip of novel construction that is connected to the penetrating sub-assembly and functions to control the rate of flow of medicinal fluid to the patient. Disposed within the housing is a second assembly that includes a shuttle, a collapsible container carried by the shuttle and a plurality of variable force springs that function to thrust the collapsible container into penetrating engagement with the penetrating member of the penetrating assembly and then to collapse the collapsible container to deliver the medicinal fluid to the patient. Connected to the second end of the housing is a novel third assembly that includes an operating member that functions to controllably move the shuttle forwardly of the housing.

Apparatus for dispensing medicinal fluids and method of making same

A dispensing device and the method of making same for dispensing medicaments to a patient that includes a housing, a first assembly connected to the first end of the housing that includes a body portion, and a penetrating sub-assembly. The first assembly also includes a rate control chip of novel construction that is connected to the penetrating sub-assembly and functions to control the rate of flow of medicinal fluid to the patient. Disposed within the housing is a second assembly that includes a shuttle, a collapsible container carried by the shuttle and a plurality of variable force springs that function to thrust the collapsible container into penetrating engagement with the penetrating member of the penetrating assembly and then to collapse the collapsible container to deliver the medicinal fluid to the patient. Connected to the second end of the housing is a novel third assembly that includes an operating member that is threadably connected to the shuttle. The operating member functions to controllably move the shuttle forwardly of the housing. The apparatus also includes a novel locking mechanism that releasably locks the operating member against rotation relative to the shuttle.

A dispensing device for dispensing pain management medicaments to a patient comprises first and second threadably interconnectable sub-assemblies. The first of these sub-assemblies houses a fluid reservoir defining component while the second comprises a fluid delivery and control assembly that includes a novel flow control means that functions to control the flow of medicinal fluid from the fluid reservoir of the first sub-assembly toward the patient via strategically formed flow control passageways.

Fluid dispenser

A novel dispensing system for dispensing medicaments to a patient that includes means for controllably heating fluid medicaments within the dispensing system by converting a chemical component, such as calcium chloride or the like, into a solution or solvent by adding a suitable solution or solvent to create an exothermic process causing an increase in temperature of the mixed solution.

Fluid dispenser with non-electric fluid heating component

A dispensing device for dispensing pain management medicaments to a patient comprising first and second threadably interconnectable sub-assemblies. The first of these sub-assemblies houses a novel collapsible fluid reservoir defining component while the second comprises a fluid delivery and control assembly that includes a novel flow control means that functions to control the flow of medicinal fluid from the fluid reservoir of the collapsible reservoir defining component toward the patient via a plurality of fluid flow control passageways.

Pain management dispenser

A compact fluid dispenser for use in controllably dispensing fluid medicaments such as antibiotics, blood clotting agents, analgesics, and like medicinal agents from collapsible containers at a uniform rate. The dispenser includes a novel stored energy source that is provided in the form of a compressible-expandable member that functions to continuously and uniformly expel fluid from the apparatus reservoir. The apparatus further includes a novel fluid flow control assembly that precisely controls the flow of the medicament solutions from the apparatus reservoir to the patient.

Fluid delivery device with variable force spring

A compact fluid dispenser for use in controllably dispensing fluid medicaments, such as antibiotics, blood clotting agents, analgesics, and like medicinal agents from collapsible containers at a uniform rate. The dispenser includes a novel stored energy source that is provided in the form of a compressible-expandable member that functions to continuously and uniformly expel fluid from the apparatus reservoir. The apparatus further includes a novel fluid flow control assembly that precisely controls the flow of the medicament solutions from the apparatus reservoir to the patient.

Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a substrate. A nanofilm may also be prepared by coupling the oriented macrocyclic modules to provide a membrane.

Nanofilm and membrane compositions

Certain macrocyclic modules comprising 3-24 synthons are provided herein. Each synthon is independently selected from cyclic substituents, wherein each synthon selected is bonded to the next through a linker to form a closed ring that defines a pore. One or more lipophilic moieties and one or more hydrophilic moieties are bonded to one or more of the synthons, resulting in the formation of the desired macrocyclic modules. Those modules may be subsequently linked to one another to form selectively-permeable membranes. Membranes comprising macrocyclic modules may be useful in filtering certain molecular species from a solution. Selective passage of particular species is determined, in part, by the size of the module's pore and the nature of the lipophilic/hydrophobic species attached thereto. Also provided are methods of making and using macrocyclic modules and membranes.

Macrocyclic modules comprising linked cyclic synthon units for use in the formation of selectively permeable membranes

A flow control device that is uniquely capable of providing uniform flow under changing environmental conditions of temperature and pressure. The device achieves flow rate stabilization by taking advantage of the properties of the moving fluid in a channel with eddy currents that are generated as fluid moves past obstacles located in the fluid flow path. The shape and magnitude of such eddies depend on the viscosity of the fluid. Additionally, the device can also simultaneously stabilize the fluid flow rate under varying pressure by using a strategically positioned, yieldably deformable elastomeric membrane. Therefore, the invention uniquely combines two devices into one novel fluidic device that can stabilize a flow rate under simultaneously changing temperatures and pressures.

Fluid flow control device

A distal rate control device, which can be conveniently interposed between a fluid supply line and fluid delivery line for precisely controlling the rate of fluid flow toward the delivery line. The device includes a readily adjustable flow rate control device having a novel flow control plate that can be placed in fluid communication with the fluid supply line and with the fluid delivery line. The flow control plate is provided with a plurality of elongated fluidic flow control channels that are in communication with a rate selector member that is rotatably carried by the device housing. Rotation of the rate selector member places a selected one of the flow control channels in communication with the fluid delivery line.

Distal rate control device

Nanoflims useful for filtration are prepared from amphiphilic species and one or more polymeric components. The amphiphilic species or components may be oriented on an interface or surface. A nanofilm may be prepared by coupling one or more of the components. The nanofilm may also be deposited or attached to a substrate.

Nanofilm compositions with polymeric components

Certain amphiphilic modules comprising 3-24 synthons are provided herein. Each synthon is independently selected from aryl, heteroaryl, alicyclic, and heteroalicyclic substituents, wherein each synthon selected is bonded to the next through a linker to form a closed ring that defines a nanopore. One or more lipophilic moieties and one or more hydrophilic moieties are bonded to one or more of the synthons, resulting in the formation of the desired amphiphilic modules. Those modules may be subsequently linked to one another to form two-dimensional close-packed planar arrays, referred to as nanomembranes. Nanomembranes may be useful in filtering certain ionic species from a solution. Selective passage of particular species is determined, in part, by the size of the module's nanopore and the nature of the lipophilic/hydrophobic species attached thereto. Also provided are methods of making and using amphiphilic modules and nanomembranes.

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Oakland, CA, United States of America

Donald B Bivin