Intraop Medical Corporation

Donald Allen Goer

James A Nelson

David H Whittum

Alexandre S Kretchetov

Christopher J Patane

Alexandre S Krechetov

Derek T DeScioli

Kenneth W Brooks

The present invention provides strategies to use and control the delivery of ionizing radiation to carry out therapeutic and industrial irradiation treatments. The present invention uses partial pulse control, component selection, and/or component configuration strategies in order to accurately monitor and terminate irradiation. The strategies are particularly useful to control dosing in the high dose rate and short time scales associated with FLASH technology.

Methods and systems for using and controlling higher dose rate ionizing radiation in short time intervals

The present invention provides electron beam therapies with improved feedback control that delivers controlled and adjustable doses of electron beam radiation to variable shallow depths with little radiation exposure to both nearby tissues and tissues below the target. In order to control radiation to accurately penetrate to shallow depths and to allow the radiation to be adjusted to other depth settings in very small or even continuous increments, the present invention senses a plurality of different electron beam characteristics and then uses these to derive a composite characteristic, or analog, of the electron beam energy. The composite analog provides a strong correlation to energy that allows this precision. In another aspect, the present invention relates to implementing this feedback control by adjusting power levels used to establish the electron beam. In other embodiments, feedback control adjusts absorbing components with variable electron beam absorption depending on how such components are presented to the electron beam.

Low energy electron beam radiation system that generates electron beams with precisely controlled and adjustable penetration depth useful for therapeutic applications

The invention discloses a method of treating cancer in a patient, comprising administering to the patient a radiation sensitizer selected from nitroimidazoles in an amount effective to sensitize a patient to radiation and subjecting the patient to radiation therapy. In certain embodiments the radiation sensitizer is etanidazole or doranidazole.

Radiotherapy combined with hypoxic cell sensitizers

The present invention relates to methods and systems for use of an electron beam system. The electron beam system may be used within a treatment center with very little radiation shielding. The electron beam system may be used in conjunction with low-z moderators that reduce the energy level of the electron beam without the need for complex or expensive energy control systems. The electron beam system may be used to treat skin cancer and dermatological patients in non-traditional treatment facilities, as well as invasive cancers, either in an unshielded operating room to deliver intraoperative radiation therapy ('IORT') or in an unshielded room in the oncology department to deliver electron beam radiation treatment ('EB-RT').

Growing community of inventors

Sunnyvale, CA, United States of America

Donald Allen Goer