Trio Medicines Limited

Cellcentric Limited

Donald Alan Gilbert

David Wood

Liv Thomsen

Malcolm James Boyce

David Michel Adrien Taddei

Gareth Harbottle

John Paul Madeley

James Vaughan Morey

Jonathan Trevorrow

Paul Baguley

Colin Lindley

A process for producing a compound of the following formula (I) which process comprises: (a) treating a compound of the following formula (5) with a compound of the following formula (6) to generate an intermediate compound of the following formula (7); (b) treating a compound of formula (7) as defined above with a compound of the following formula (8); and (c) recovering a compound of formula (I) as defined above. The compound of formula (I) is a promising modulator of p300/CBP activity that has potential utility in treating cancers, including prostate cancer, haematological cancers, bladder cancer and lung cancer. 

Process for preparing modulators of p300 and/or CBP

The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I: 

Synthesis of benzodiazepine derivatives

The invention relates to benzodiazepine derivatives of formula (A) useful as CCK/gastrin receptor antagonists, their preparation and their use in the treatment or prevention of disorders associated with CCK/gastrin receptors, disorders caused by or associated with hypergastrinaemia, and gastric acid-related disorders. 

Benzodiazepine derivatives as CCK2/gastrin receptor antagonists

The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I: (I) 

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Ipswich, United Kingdom

Donald Alan Gilbert