Minnetronix, Inc.

Basis Science, Inc.

Pulse Tracer, Inc.

Don W E Evans

Richard A Nazarian

Nathan J Bolyard

Thomas P Sutera

Lori E Lucke

Corey D Brown

Mark J Bina

Michael W Geatz

Susan S Alfini

Paul Harris

Timothy A Bachman

Michael A Knipfer

Douglas Scott Wahnschaffe

Reed Allan Houge

Abhi Vase

Mark Schneider

David J Hansen

Kenneth E Broen

Jeremy John Maniak

Scott Klimek

Anne F Mickelson

Systems and methods for systems and methods for focal cooling of the brain and spinal cord are disclosed. Some embodiments may be directed to a neuroprotection system that includes a cerebrospinal fluid processing platform. Embodiments may provide rapid and selective spinal cord hypothermia and drainage. Embodiments may be tailored to selective spinal cord cooling, pressure monitoring and automated drainage. Embodiments may enable local hypothermic neuroprotection, limit the stress of systemic cooling, minimize secondary neuronal damage and achieve maximal neuroprotection while at the same time improving workflow as a result of automated drainage. Embodiments may include a multi-lumen catheter, a drainage collection reservoir bag, a pump to circulate coolant, sensor hardware and controllers to modulate the flow of a heat transfer fluid for cooling to modulate therapeutic hypothermia and re-warming. Certain embodiments may include extracorporeal cooling of cerebrospinal fluid (CSF). Certain embodiments may include circulating heat transfer fluid within a CSF-containing space near the brain or spinal cord using a catheter. Particular methods may be used to determine the length and amount of cooling.

Devices and methods for providing focal cooling to the brain and spinal cord

A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured for variable form factors to accommodate a variety of wearable configurations for patient convenience and comfort.

Portable controller and power source for mechanical circulation support systems

A pump for inducing flow within a vascular system comprises a cannula having a first configuration for deployment within the vascular system and a second configuration for directing the fluid flow within the vascular system, where the second configuration has a greater diameter than the first configuration. An impeller is configured to induce the fluid flow by rotation about an axis. The impeller has a first radius in the first configuration and a second radius in the second configuration, where the second radius is greater than the first radius.

Expandable vascular pump

A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.

Portable controller with integral power source for mechanical circulation support systems

A pulse rate sensor that includes an accelerometer for measuring periodic motion and a piezo sensor for detecting erratic motion is capable of more accurately determining pulse rate by accounting for these types of motion. The pulse rate sensor in accordance with the present invention diminishes pulse rate signal degradation due to erratic motion through a combination of algorithms that control signal boosting, waveform refinement and signal noise suppression.

Motion cancellation of optical input signals for physiological pulse measurement

A pump for inducing flow within a vascular system comprises two inlets. The pump has a first configuration for deployment within the vascular system and a second, operable configuration for directing the fluid flow within the vascular system, where the second configuration has a greater diameter than the first configuration. A centrifugal impeller is configured to induce the fluid flow by rotation about an axis of rotation, where the flow is in a direction generally transverse to the impeller's axis of rotation.

Expandable blood pump for cardiac support

A pump for inducing motion of a fluid, the pump including a cannula adjustable between an operable configuration having a first diameter and a deployment configuration having a substantially smaller second diameter. An impeller is rotatable within the cannula about an axis. The impeller includes an at least semi-rigid support for a flexible web, and is positionable with respect to the cannula the operable configuration and the deployment configuration, the operable configuration extending the web to a first radial distance from the axis and the deployment configuration collapsing the web to a second substantially smaller radial distance from the axis.

Expandable blood pumps and methods of their deployment and use

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Saint Paul, MN, United States of America

Don W E Evans