Genentech, Inc.

Oregon Health & Science University

Oregon Regional Primate Research Center

Medical Research Foundation of Oregon

Don P Wolf

Teresa K Woodruff

Richard L Stouffer

Baha M Alak

James Anthony Byrne

Shoukhrat M Mitalipov

Purified totipotent stem cells and pluripotent stems cells derived by somatic cell nuclear transfer are disclosed herein, as well as cell lines, multipotent cells and differentiated cells produced from these stem cells. The stem cells are produced from an enucleated host cell from a first donor and nuclear genetic material from a somatic cell of a second donor. Methods for making and using such compositions of such stem cells are also provided.

Primate pluripotent stem cells produced by somatic cell nuclear transfer

A method is provided for increasing the fertilization potential of oocytes comprising culturing oocytes in vitro with an effective amount of inhibin, activin, or a combination of inhibin and activin. Preferably the oocytes being cultured are immature. After the culturing step, the oocytes can be fertilized. The oocytes are suitably cryopreserved and thawed before the culturing step.

Enhancement of fertilization capability of oocytes

Use of human inhibin and human activin to increase the number of mature

Growing community of inventors

Portland, OR, United States of America

Don P Wolf