Smithkline Beecham Corporation

Smithkline Beckman Corporation

Anormed, Inc.

Don Edgar Griswold

Paul E Bender

Nabil Hanna

Jerry Leroy Adams

John C Lee

David C Underwood

Michael J Bower

Jeffrey Charles Boehm

Ralph F Hall

Henry M Sarau

Alison Mary Badger

John G Gleason

Ivan Lantos

Klaus M Esser

Philip L Simon

Susan C Shilcrat

Kazys A Razgaitis

John Wharton

Bartholomew J Votta

Novel substituted quinazoline compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.

3,4-Dihydro-(1H) quinazolin-2-one compounds as CSBP/P38 kinase inhibitors

3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors

Substituted quinazolinone compounds of formula (I) and compositions thereof for use in therapy as CSBP/p38 kinase inhibitors.

The present invention relates to 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolines of formula (1), or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors

Invented is a method of treatment of psoriasis in a mammal in need thereof which comprises administering to such mammal an effective amount of a substituted azaspirane.

Methods of treating psoriasis employing substituted azaspiranes

Method for treating atopic dermatitis and contact dermatitis

The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for the treatment of chronic inflammatory disease states.

Medicaments

Inhibition of interleukin-1 and tumor necrosis factor production by

A method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a diaryl- substituted imidazole fused to a thiazole pyrrolidine, thiazide or piperidine ring to such animal.

Inhibition of the 5-lipoxygenase pathway

A method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a diaryl-substituted imidazole fused to a thiazole pyrrolidine, thiazide or piperidine ring to such animal.

Inhibition of interleukin-1 production by monocytes and/or macrophages

A method of inhibiting the production of interleukin-1 by monocytes in a human in need thereof which comprises administering to such human an effective interleukin-1 production inhibiting amount of a 4,5-diaryl-2(substituted)imidazole.

Inhibition of interleukin-1 by monocytes and/or macrophages

A method of inhibiting the production of interleukin-1 by monocytes and/or macrophages in a human in need thereof which comprises administering to such human an effective interleukin-1 production inhibiting amount of a 2-2'-[1,3-propan-2-onediyl-bis(thio)]bis-1H-imidazole or a pharmaceutically acceptable salt thereof.

Novel compounds, compositions and pharmaceutical a method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprising administering an effective, 5-lipoxygenase pathway inhibiting amount of a 4,5-diaryl-2(substituted)-imidazole or a pharmaceutically acceptable salt thereof.

Growing community of inventors

North Wales, PA, United States of America

Don Edgar Griswold