The University of British Columbia

British Columbia Cancer Agency Branch

Don D Sin

Stephen C-t Lam

Bruce McManus

Raymond Ng

Zsuzsanna Hollander

Virginia Chen

Marianne Dorthy Sadar

John Yee

Michael Kuzyk

Carl Martin Tammemagi

Described are compositions and methods for diagnosing acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Multiple reaction monitoring mass spectrometry (MRM-MS) was used to quantify the amount of protein biomarkers in plasma samples from human subjects. The amount of the biomarkers in the sample can distinguish AECOPD from a stable or convalescent state of COPD, or from a subject without COPD.

Methods and systems of detecting plasma protein biomarkers for diagnosing acute exacerbation of COPD

A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.

Methods for detecting lung cancer and monitoring treatment response

Growing community of inventors

Vancouver, Canada

Don D Sin