Haemonetics Corporation

Dominique Uhlmann

Etienne Pagès

Michael Ragusa

Matthew J Murphy

Edward T Powers

Etienne Pages

Toshiyasu Ohashi

Pascal Maillard

Shiven Ruparel

A continuous flow centrifuge bowl includes a rotatable outer body, and a top and bottom core that are rotatable with the outer body. The bottom core has a wall extending proximally from a bottom wall. The proximally extending wall is radially outward from at least a portion of the top core and, together with the top core, defines a primary separation region in which initial separation of the whole blood occurs. The bowl may also have a secondary separation region located between the top core and the outer body, and a rotary seal that couples an inlet port and two outlet ports to the outer body. The inlet port may be connected to an inlet tube that extends distally into a whole blood introduction region. Additionally, one of the outlet ports may be connected to an extraction tube that extends into a region below the bottom core.

Continuous flow separation chamber

A method for continuously washing packed red blood cells includes (1) transferring, at a first flow rate, packed red blood cells from a container to a separation device and (2) transferring, at the same time as the packed red blood cells, wash solution from a container to the separation device. The wash solution may be transferred at a second flow rate that is greater than the first flow rate. The wash solution mixes with the packed red blood cells within the inlet line of the separation device and dilutes/washes the packed red blood cells. The separation device separates the red blood cells from the wash solution and a supernatant. The method may then monitor the volume of washed red blood cells within the separation device and begin to extract the washed red blood cells into a red blood cell product container when a target volume is collected within the separation device.

System and method for continuous flow red blood cell washing

Continuous flow separation chamber with optical sensor

Continuous flow separation chamber with weir disk

A method for washing platelets includes introducing anticoagulant into a platelet product container, drawing re-anticoagulated platelet product from the platelet product container, and introducing it into a centrifuge bowl. The centrifuge bowl separates the platelets from the supernatant in which they are suspended. The method then washes the platelets by introducing wash solution into the centrifuge bowl. As the wash solution is introduced into the bowl, it displaces the supernatant from the bowl and into a waste container. The method then introduces platelet additive solution into the centrifuge bowl, which displaces the wash solution from the centrifuge bowl and into the waste container and further wash the platelets. The method then repeatedly accelerates and decelerates the centrifuge bowl to resuspend the platelets in the platelet additive solution.

System and method for automated platelet wash

An apparatus for separating whole blood includes an access device for drawing whole blood from a source, a blood component separation device, a draw line, a draw pump, and a controller. The blood component separation device separates the drawn whole blood into a first blood component and a second blood component. The draw line fluidly connects the access device and the blood component separation device, and the draw pump draws whole blood from the source through the access device and draw line and into the blood component separation device. The controller controls fluid flow through the apparatus and operation of the draw pump. The controller also monitors the total volume of whole blood drawn from the source and the total volume of first blood component collected. The controller stops the draw pump when the first of a target whole blood volume is withdrawn or a target volume of first blood component is collected.

System and method for automated separation of whole blood

A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.

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Abington, MA, United States of America

Dominique Uhlmann