Bristol-myers Squibb Compnay

Cerep Sa

Laboratoires Upsa

Other

Laboratoires Uspa

Dominique Potin

Michele Launay

T G Murali Dhar

Eric Nicolai

Edwin J Iwanowicz

Magali Jeannine Blandine Maillet

Jean-Marie C Teulon

Nicole Bru-Magniez

Dharmpal S Dodd

Scott Hunter Watterson

Zili Xiao

Pyrrolizine compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective in treating inflammatory or immune diseases, where A is a four- to seven-membered saturated ring, K is O or S, and R, R, Rn, and M are defined in the specification.

Pyrrolizine compounds useful as anti-inflammatory agents

The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K and L are independently, O or S; Q is &#x2014;C(&#x2550;O)&#x2014; or optionally substituted Calkylene; Ar is optionally-substituted aryl or heteroaryl; J, J, Jand Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; Ris N or C(R); and R, and R, are as defined in the specification.

Spiro-cyclic compounds useful as anti-inflammatory agents

A class of substituted spiro-hydantoin compounds (II) having the formula: its pharmaceutically acceptable salts, enantiomers, solvates, or prodrugs thereof, wherein Ris a substituted pyridinyl group, as defined herein, is provided. Pharmaceutical compositions and methods of treating anti-inflammatory and/or immune diseases with the pyridyl-substituted spiro-hydantoin compounds are also objectives of this invention.

Pyridyl-substituted spiro-hydantoin compounds and use thereof

Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R, R, R, and Rare as defined in the specification.

Spiro-hydantoin compounds useful as anti-inflammatory agents

Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof,are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R,R, R, and Rare as defined in the specification.

The present invention is directed to compounds having the formula (I):useful in treating inflammatory and immune diseases, in which K is O or S; Q is &#x2014;C(&#x2550;O)&#x2014; or optionally substituted Calkylene; Ar is optionally-substituted aryl or heteroaryl; J, J, J, and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; Z is N or C(R); and R, R, Rand Rare as defined in the specification.

Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents

Hydantoin compounds useful as anti-inflammatory agents

Urazole compounds useful as anti-inflammatory agents

The present invention relates to the carbocyclic diarylmethylene derivatives of formula (I): ##STR1## and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.

Carbocyclic diarylmethylene derivatives, processes for their preparation

The present invention relates to the derivatives of the formula ##STR1## and their addition salts, and to their use in therapeutics, especially as drugs with analgesic properties.

Piperidinylthioindole derivatives, their methods of preparation and

The present invention relates to the derivatives of the formula ##STR1## and their addition salts, and to their use in therapeutics, especially as drugs having analgesic properties.

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Epone, France

Dominique Potin