The University of Chicago

Janssen Pharmaceuticals, Inc.

Dominique Missiakas

Olaf Schneewind

Alice G Cheng

Hwan Keun Kim

Carla Emolo

Andrea Dedent

Molly McAdow

Jeroen Geurtsen

Hye-Young Kim

Mark De Been

Monica Burts

Lena Thomer

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant.

Compositions and methods related to protein A (SpA) variants

Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.

Compositions and methods related to antibodies that neutralize coagulase activity duringdisease

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.

Staphylococcal coagulase antigens and methods of their use

Compositions and methods related to Protein A (SpA) Variants

Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA).

Compositions and methods related to antibodies to Staphylococcal protein A

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant or an antibody directed thereto.

Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response

Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria, in certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa).

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Disclosed are methods and compositions for treating or preventing abacterial infection using a non-toxigenic Protein A (SpA) variant.

Compositions and methods related to antibodies to staphylococcal protein A

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant. In some embodiments, the methods and compositions involve SdrD, ClfA, and/or FnbpB polypeptides.

Methods and compositions involving protective staphylococcal antigens

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve an Ebh antigen.

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Chicago, IL, United States of America

Dominique Missiakas