Commissariat a L'energie Atomique

Biomerieux, Inc.

Dominique Masse

Frederic Ginot

Arnelle Novelli-Rousseau

Colette Charbonnier

Severine Moutin

The invention relates to a method of reading, detecting or quantifying at least one biological reaction, on a support, between either a recognition molecule and a labeled target molecule or between a target molecule and a labeled detection molecule. The inventive method comprises treating the support under physicochemical conditions that allow the following: either the separation of the recognition molecule and the labeled target molecule or the separation of the target molecule and the labeled detection molecule. The inventive method further comprises producing images before and after the physicochemical treatment that can be used to determine the specific and non-specific bindings between the different molecules. The invention also relates to hybrids and complexes used in the inventive method and to a biochip containing the same which is used to carry out the inventive method. The invention is particularly suitable for use in the field of diagnosis.

Reading, detection or quantification method, hybrids or complexes used in said method and the biochip using same

The invention concerns a device for measuring the position of the fixing point (P') of an eye on a video screen (19) comprising: a mobile support (10) positioned close to the eye and on which first illumination means (12) and a video camera (11) are fixed so as to embody images of the eye, and a fixed support (17) distant from the eye and on which the video screen orientated opposite the eye and a plurality of luminous sources illuminating the eye in alternative with the first illumination means are positioned and disposed around the video screen so as to create on the eye corneal reflections and means (20) for treating the images obtained from the eye. The invention also concerns an eye illumination method in which the eye is illuminated by flashes each emitted at the end of each taking of images, as well as an application of the device for displaying on the video screen images which change according to the movements of the eye wherein a high resolution zone (Z) is defined around the fixing point (P') and for moving this zone according to the movements of the eye. Application for the medical sphere, ergonomics and interactive data processing.

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Coublevie, France

Dominique Masse