Laboratoires Des Produits Ethiques Ethypharm

Laboratoires Des Products Ethiques Ethypharm

Dominique Marechal

Pascal Suplie

Pascal Oury

Christophe Lebon

The present invention concerns a novel sustained-release oral formulation of morphine sulphate in the form of microgranules. Each microgranule comprises a neutral support grain coated with an active layer and with a sustained-release layer, characterized in that the sustained-release layer contains a copolymer of methacrylic acid and of methyl methacrylate ester, the relative proportion of the free carboxyl groups and of the ester groups of which is equal to 0.5 approximately, and a silica exhibiting a hydrophobic character. The present invention also concerns a process for preparing these microgranules which is carried out entirely in aqueous medium by emplacing on neutral support grains.

Morphine sulphate microgranules, method for preparing same and compositions containing same

The invention concerns ketoprofen microgranules with prolonged release each consisting of an active core containing ketoprofen coated with a polymeric film enabling prolonged release of the active principle and containing acrylic polymer coatings in a volume proportion substantially equal to 90/10.

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Dreux, France

Dominique Marechal