Institut National De La Sante Et De La Recherche Medicale

Centre National De La Recherche Scientifique

Institut Pasteur

Assistance Publique-hopitaux De Paris

Université Paris Diderot-Paris 7

UniversitÉ De Paris

Universite Paris 13 - Paris Nord

Inserm

Dominique Le Guludec

Sylvie Bay

Giuseppina Caligiuri

Martine Jandrot-Perrus

Antonino Nicoletti

Philippe Billiald

Julien Muzard

Alain Meulemans

Jonathan Vigne

Laure Sarda

Martine Jandrot-perrus

Disclosed is CD31for use as a molecular imaging target in the molecular imaging of an inflammatory condition. Administering the radiolabeled peptide P8RI as CD31ligand in different rat models of inflammation indeed showed that CD31is present on activated cells in a quantity allowing a detectable signal, whereas the noise signal corresponding to CD31present on activated circulating cells and on other organs or cells not involved in inflammation was little. Also disclosed is a labeled CD31ligand and the use thereof as a molecular imaging agent in the molecular imaging of an inflammatory condition. The molecular imaging of inflammatory sites particularly allows determining whether a subject suffers from or is at risk of having an inflammatory condition or is at risk of recurrence of an inflammatory condition after an anti-inflammatory treatment.

CD31as a molecular target for imaging of inflammation

The present invention relates to diagnostic imaging and in particular to the diagnostic imaging of fibrosis. More particularly, the present invention provides a polypeptides, cyclic polypeptides and pharmaceutical compositions suitable for the non-invasive visualization of fibrosis. The polypeptide of the invention may comprise an amino acid sequence consisting of: X1-X2-M-H-G-L-X7-L-X9-X10-D-E (SEQ ID NO: 1) wherein amino acid X1 is R, F or P; amino acid X2 is F or V; amino acid X7 is Q, H or L; amino acid X9 is W or G and amino acid X10 is A or D.

Polypeptides, cyclic polypeptides and pharmaceutical comprising thereof for non invasive specific imaging of fibrosis

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Paris, France

Dominique Le Guludec