Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Les Laboratoires Servier

Les Laboratories Servier

Institut National De La Santè

Institut National De La Sante Et De La Recherche Medicale (inserm)

Progastrine Et Cancers S.a R.l.

Dominique Joubert

Frédéric Hollande

Julie Pannequin

Laure Boudier

Frederic Hollande

Leïla Houhou

Leila Houhou

Françoise Cailler

Jean-Francois Floch

Bérénice Framery

Jean-François Floch

Nejla Erkilic

Anne-Sophie Dumé

Mathieu Petremann

Anne-Sophie Dume

The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or fragments thereof. The present disclosure is further directed to methods comprising detection of progastrin, including methods of diagnosing colorectal cancer and methods of monitoring efficacy of anti-cancer therapy in subjects suffering from colorectal cancer.

Monoclonal antibodies to progastrin and their uses

The present disclosure provides methods of treating liver cancer and preventing liver cancer recurrence with anti-progastrin antibodies, methods of monitoring treatment efficacy of anti-progastrin therapy for liver cancer, and compositions useful therefore.

Methods and compositions for liver cancer therapy

The present disclosure provides methods and compositions useful for preventing gastrointestinal and/or colorectal cancer in animals, including humans, having pre-cancerous adenomatous polyps. The present disclosure provides compositions comprising anti-PG antibodies suitable for use in the methods of the disclosure. The present disclosure also provides methods and compositions useful for monitoring the efficacy of anti-PG treatment in subjects with pre-cancerous polyps.

Prophylaxis of colorectal and gastrointestinal cancer

The present disclosure is directed to methods of treating pancreatic cancer in subject using cancer with antibodies that specifically bind to progastrin.

Methods for treating pancreatic cancer

The present disclosure is directed to methods of treating and preventing colorectal cancer metastasis or recurrence of colorectal cancer with compositions comprising anti-progastrin antibodies.

Methods for treating colorectal cancer

The present disclosure is directed to methods of treating and preventing breast cancer or recurrence of breast cancer with compositions comprising anti-progastrin antibodies.

Methods for treating breast cancer

Growing community of inventors

Sète, France

Dominique Joubert