Association Pour L'essor De La Transfusion Sanguine Dans La Region Du

Centre Regional De Transfusion Sanguine De Lille

Efs Nord De France

Dominique Dernis

Thierry Burnouf

Miryana Burnouf-Radosevich

Catherine Michalski

Patrick Bonneel

Immunoglobulin G concentrate for therapeutic use and process for

The invention relates to a process for preparing purified albumin from a human or animal physiological solution, such as a plasma or a plasma fraction. The process includes a process of delipidation using an anionic detergent and two chromatographic separation stages using ion-exchange resin. By applying the process according to the invention, it is possible to obtain an albumin solution of great purity, that is stable and suitable for therapeutic use.

Process for the preparation of purified albumin solutions

Process for preparing a human thrombin concentrate from the PPSB fraction of plasma that does not involve any addition of factors of animal origin to induce activation of the prothrombin to produce thrombin, and which includes a viral inactivation step using solvent-detergent and purification by cation exchange chromatography. The choice of a protective medium ensures the high specific activity of the final product. The thrombin concentrate obtained using this process is intended for therapeutic use, either alone, to serve as a local hemostatic agent, or in combination with a fibrinogen concentrate to form biological glue.

Process for preparing a human thrombin concentrate intended for

The invention relates to a human Factor XI concentrate having high specific activity prepared using a process comprising a filtration-adsorption step and a single step of chromatography on cation exchange resin. The concentrate obtained is perfectly suitable for therapeutic use in replacement therapy in cases of Factor XI deficiency.

Blood coagulation factor XI concentrate having high specific activity,

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Marquette-Lez-Lille, France

Dominique Dernis