Teva Pharmaceutical Industries Limited

Ire-medgenix S.a.

Dominique Delacroix

Henri Wantier

Fabienne Mathieu

Marc Baudrihaye

Donat De Groote

Paul Franchimont

Aimee Reuter

Isabelle Dehart

Philippe Gysen

Microspheres which are a matrix of a biocompatible and biodegradable polymer which is soluble in an organic solvent which is immiscible in water, within which a water-soluble substance is uniformly distributed, and wherein the residual level of toxic solvent in the microspheres is lower than 1.5% by weight, progressively and continuously releases the substance over a period of at least 8 days when the microspheres are placed in an aqueous physiological environment, with a reduced or substantially absent first phase of accelerated release. A process for producing such microspheres is provided.

Microspheres for the controlled release of water-soluble substances and

The subject of the present invention is a process for preparing microparticles of the microsphere type of a water-soluble substance and a biocompatible and biodegradable polymer controlling the kinetics of release of the said substance consisting of a matrix of the said polymer within which the said water-soluble substance is regularly dispersed, characterized in that

Preparation of microparticles for controlled release of water-soluble

Assay of monokines

Growing community of inventors

Kraainem, Belgium

Dominique Delacroix