Centre National De La Recherche Scientifique

Universitë De Bordeaux

UniversitÉde Strasbourg

Institut Polytechnique De Bordeaux

Dominique Burnouf

Gilles Guichard

Vincent Olieric

Annick Stote

Jerôme Wagner

Jérôme Wagner

Jerome Wagner

The present invention relates to a fusion peptide having one of the following formulae: P1-L-P2 (I) or P2-L-P1 (II) wherein P1 is chosen from the proline-rich antimicrobial peptides; Lisa peptide linker; and P2 has the following formula (III): wherein m is 0 or 1; n is an integer comprised between 0 and 9; p is an integer comprised between 0 and 10; r is 0, 1 or 2; s is 0 or 1; Gln is glutamine; Ris the side chain of arginine or lysine; Ris for example a —(CH)—C-cycloalkyl group optionally substituted; Ris for example a C-alkyl group; Ris in particular a C-alkyl group optionally substituted by a C-cycloalkyl group; Ris for example a —(CH)—C-cycloalkyl group; Ris in particular —COOH, wherein, when the fusion peptide has the formula (II), its C-terminus contains a —CO— group engaged in a peptide bond with said linker.

Fusion peptides as antimicrobial agents

The present invention relates to compounds which bind to the hydrophobic pocket of the &#x3b2; clamp, i.e., to the surface of the &#x3b2; ring with which said protein interacts with other proteins of the bacterial replication complex during DNA replication. These compounds are derived from the acetylated peptide AcQLDLF (P6) to improve their affinity to their target.

Compounds binding to the bacterial beta ring

Growing community of inventors

Brumath, France

Dominique Burnouf