Immune Targeting Systems Ltd.

Altimmune UK Limited

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Universitéde Strasbourg

Université Paris—sud

Institut Pasteur De Lille

Centre International De Recherche Aux Frontieres De La Chimie

Usinor Sa

Inserm (institut National De La Sante Et De La Recherche Medicale)

College De France

Dominique Bonnet

Philip J Sizer

Carlton B Brown

Bertrand Georges

Carlton Bradley Brown

Bertrand V Georges

Marcel Hibert

Sylviane Muller

Bertrand Victor Gilbert Georges

Oleg Melnyk

Jean-Luc Galzi

Jacques-Yves Bourgon

Fabrice Tondo

Christophe Guignabert

Nelly Frossard

Line Bourel

Gilbert Petig

Hélène Gras-Masse

Pierre Vienot

Frédéric Simonin

Christophe Noardo

Catherine Llorens Cortes

Xavier Iturrioz

Catherine Llorens-cortes

Glenn-Marie Le Coz

Lucie Estéoulle

The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals.

Antigen delivery vectors and constructs

A subject of the present invention is a compound having the general formula (I):  Another subject of the invention is the compound as defined above for use as a medicament, in particular for preventing and/or treating inflammation and inflammatory diseases, immune and auto-immune diseases, pain related diseases, genetic diseases and/or cancer.

Pyrimidinone derivatives and uses thereof to neutralize the biological activity of chemokines

The present invention relates to fluorocarbon vectors for the delivery of influenza antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-influenza antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals, including humans.

Influenza antigen delivery vectors and constructs

The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the lipophilic vector. The invention also concerns lipophilic vectors for use in this method, lipopeptides obtained by this method, uses of the lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.

Method for binding, in solution, a peptide and a lipophilic vector and uses thereof

A metal measurement plate (), having a size suitable for being placed between the set of upper rolls and the set of lower rolls of the leveler, has positioning means () for positioning it with respect to the rolls in the leveling direction, and strain gauges () for measuring elastic deformations of the plate during clamping on the leveler, said strain gauges being fastened to the plate so as to form several transverse rows of gauges (to) each located vertically in line with one of said rolls, on the opposite face of the plate with respect to said roll.

Device and method for calibrating a multiple-roller flattener

Growing community of inventors

Geispolsheim, France

Dominique Bonnet