Pharmacia Corporation

Pfizer Corporation

Pharmacia & Upjohn Company

Dominique Bonafoux

Patrick J Lennon

Gunnar J Hanson

Michael L Vazquez

Michael John Clare

Richard M Weier

Richard A Partis

Timothy J Hagen

Walter Morozowich

Michael B Tollefson

Suzanne S Metz

Francis J Koszyk

Michael A Stealey

Malcolm Wilson Moon

Bruce C Hamper

He Huang

Xiangdong Xu

Arija A Bergmanis

Subo Liao

Lifeng Geng

Shuyuan Liao

Joyce Zuowu Crich

Michael John Hawley

Thomas Dale Owen

Stephen C Houdek

Mark Peter Warchol

Scott B Mohler

Sergey Gregory Wolfson

Serge G Wolfson

Ivan Richards

Sue K Cammarata

Donna M Iula

Craig D Wegner

Theresa R Fletcher

Mark Kontny

Angela M Scates

Karen Patrice Kolbasa

Maria Nguyen

David S Oburn

The compound 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-(trifluoromethyl) phenol may be used to prepare the compound (3R)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-N,N-diisopropyl-N-methyl-3-phenylpropan-1-aminium bromide by reaction with methyl bromide.

Phenol derivative

The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

Substituted pyrazolyl compounds for the treatment of inflammation

Novel quaternary ammonium compounds of the formulaand any stereoisomers thereof, wherein R, Rand Rindependently represent C-Calkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R, Rand Rmay form a ring together with the quaternary ammonium nitrogen; Rrepresents &#x2014;H, &#x2014;CH, or &#x2014;CO&#x2014;R, wherein Rrepresents &#x2014;(C-Calkyl), &#x2014;(C-Calkoxy), or &#x2014;NRR, wherein Rand Rindependently represent &#x2014;H or &#x2014;(C-Calkyl); R, Rand Rindependently represent &#x2014;H, &#x2014;OCH, &#x2014;OH, &#x2014;CONH, &#x2014;SONH, &#x2014;F, &#x2014;Cl, &#x2014;Br, &#x2014;I, &#x2014;CF, or &#x2014;(C-Calkyl), optionally substituted with one or two &#x2014;OH, &#x2014;(C-Calkoxy), &#x2014;COOH, or &#x2014;CO&#x2014;O&#x2014;(C-Calkyl); and Xrepresents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.

Quaternary ammonium compounds

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St. Louis, MO, United States of America

Dominique Bonafoux