Kali-chemie Pharma Gmbh

Dominique Biard

Daniel Jasserand

Marie-Odile Christen

Dimitri Yavordios

Daniel Mansuy

Patrick Dansette

Amor Sassi

The use of 5-phenyl-3H-1,2-dithiol-3-thion-S-oxides which are optionally substituted in the phenyl ring as active substances in hepato-protective medicaments and new 5-phenyl-3H-1,2-dithiol-3-thion-S-oxides which are substituted in the phenyl ring are described.

1,2-dithiol-3-thion-S-oxide compounds and pharmaceutical compositions

5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds of the Formula ##STR1## in which R.sub.1 is a straight-chain, branched or cyclic alkyl group with up to 6 carbon atoms, Z is an alkylene chain with 2 to 4 carbon atoms, and 1-phenyl substituent is an optionally substituted phenyl ring, and R.sub.4 is a phenyl or pyridyl group which is optionally substituted and their preparation are described. The compounds have pharmacological, particularly antiallergic, properties.

Antiallergic 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds

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Trivier sur Moignans, France

Dominique Biard