The General Hospital Corporation

Institut Gustave Roussy

Dominique Bellet

Jack Raymond Wands

Vladimir Lazar

Mehmet Ozturk

Jean-Michel Bidart

Michel Vidaud

A process for detecting malignant transformation of cells involves detecting the overexpression of the products of the &bgr;3, &bgr;5, &bgr;8 and &bgr;9 genes, which encode the hCG&bgr; subunit, relative to their expression in nonmalignant cells. A kit for diagnosing an hCG- or an hCG fragment-secreting cancer includes an assembly of polypeptides covering at least a part of the primary sequence of hCG. The use of a polypeptide corresponding to at least one portion of the primary sequence of hCG for producing a composition useful in hCG- or hCG fragment-secreting cancer immunotherapy is also disclosed.

Process for detecting the malignant transformation of human cells

Malignant human cell transformation detection method

The invention relates to an immunometric assay for a multivalent antigen in a sample which comprises forming a complex of the antigen together with multiple immobilized monoclonal antibodies against different epitopes of the antigen and with a detectably labeled soluble monoclonal antibody which is identical to one of the multiple immobilized antibodies. The labeled antibody associated with the complex is separated from the remaining soluble antibody and the detectably labeled antibody associated with the complex or unassociated with the complex is detected. Any one of the multiple immobilized monoclonal antibodies shows, by itself, substantially less binding towards the antigen in the immunometric assay, when used with itself or another monocolonal antibody in soluble labeled form, than when used with the multiple immobilized antibodies in combination.

Multiepitopic immunometric assay

A method for the determination of a free protein subunit of a quaternary protein in a sample, which comprises:

Method for the detection of a polypeptide subunit in the presence of a

A highly sensitive and specific monoclonal-immuno-radiometric assay (M-IRMA) for hCG, using monoclonal antibodies (Mabs) directed against a 37-amino acid synthetic polypeptide analogous to the carboxyl terminus (CTP) of beta-hCG. Accordingly, in one embodiment, a method is described for the determination of human chorionic gonadotr

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Paris, France

Dominique Bellet