Institut National De La Sante Et De La Recherche Medicale

Cis Bio International

Universitéde Strasbourg

Inserm

Justus-liebig Universität

Dominique Aunis

Jean-Christophe Antoine

Marie-Françoise Belin

Jérôme Honnorat

Michèle Aguera

Lise Roth

Laurent Bellanger

Dominique Bagnard

Fran&ccedil;ois Degorce

Cécile Nasarre

Yannick Goumon

Francis Schneider

André Sobel

Gerard Cremel

Pierre Hubert

Pappachan Kolattukudy

ThanhTam Quach

Sylvie Dirrig-Grosch

Tamara Byk

Marie-Hélène Metz-boutigue

Ingeborg Welters

Gérard Cremel

The present invention concern a peptidic antagonist of class III semaphorins/neuropilins complexes comprising an amino acid sequence, which is derived from the transmembrane domain of a protein selected in the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin Beta 1 and integrin beta 2, and including at least a GxxxG motif, eventually fused to an heterologous sequence; a nucleic acid encoding for said peptidic antagonist, a pharmaceutical composition comprising such a peptidic antagonist or a nucleic acid encoding thereof and uses thereof.

Peptidic antagonists of class III semaphorins/neuropilins complexes

The invention concerns a purified polypeptide, biologically active polypeptide derivative or fragment of said purified polypeptide, comprising an amino acid sequence selected among SEQ.ID. No. 2, No. 4, No. 6 and No. 8.

Use of ULIP proteins in the diagnosis and therapy of cancers and paraneoplastic neurological syndromes

The invention pertains to an immunoassay, and a kit for said assay, in which at least one monoclonal antibody or polyclonal antibody specifically binds to an epitope corresponding to amino acids 145 to 234 of human chromogranin A.

Human chromogranin A (CgA) immunologic assay, antibodies, reagents and kits for said assay

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Strasbourg, France

Dominique Aunis