University of Texas System

Max-delbrueck-centrum Fuer Molekulare Medizin

Max-delbrueck-centrum Fuer Molekulare Medizin (mdc)

Dominik N Mueller

John Russell Falck

Gerd Wallukat

Robert Fischer

Wolf-Hagen Schunck

Cosima Arnold

Narender Puli

Anne Konkel

Nareuder Puli

Cosima Schmidt

The present invention provides compounds (n-3 PUFA derivatives) of formula (I): that modulate conditions associated with cardiac damage, especially cardiac arrhythmias.

Eicosanoid derivatives

The present invention relates to compounds according to general formula (I) which are analogues of epoxymetabolites produced by cytochrome P450 (CYP) enzymes from omega-3 (n-3) polyunsaturated fatty acids (PUFAs). The present invention further relates to compositions containing one or more of these compounds and to the use of these compounds or compositions for the treatment or prevention of conditions and diseases associated with inflammation, proliferation, hypertension, coagulation, immune function, pathologic angiogenesis, heart failure and cardiac arrhythmias.

CYP-eicosanoid derivatives

The present invention provides compounds (n-3 PUFA derivatives) of formula (I) that modulate conditions associated with cardiac damage, especially cardiac arrhythmias. 

Growing community of inventors

Berlin, Germany

Dominik N Mueller