Agency for Science, Technology and Research

Dominik Janczewski

Ming-Yong Han

Nikodem Tomczak

Padmanabhan Parasuraman

Kishore K Bhakoo

Tamil Selvan Subramanian

G Julius Vancso

The invention generally refers to a cell-targeting nanoparticle, wherein the cell-targeting nanoparticle is directly conjugated to at least one cysteine-containing peptide, wherein the cysteine-containing peptide is selected from the group consisting of glutathione (GSM, a GSH-containing peptide, and a peptide comprising a nuclear localization signal (NLS) sequence and a transporter sequence, and methods of using the cell-targeting nanoparticle.

Cell-targeting nanoparticles and uses thereof

An amphiphilic polymer (A) comprising repeat units of the general formulae (I), (II) and (III): or salts thereof, wherein Ris H or methyl, Ris an aliphatic moiety with a main chain of 3 to 30 carbon atoms and 0 to 3 heteroatoms selected from the group N, O, S, Se and Si, and Ris one of (i) an alicyclic moiety with a main chain of 5 to 80 carbon atoms and 0 to 30 heteroatoms (ii) a moiety &#x2014;Z&#x2014;Rwherein Ris an alicyclic moiety with a main chain of 5 to 80 carbon atoms and 0 to 30 heteroatoms and Z is an aliphatic bridge of 1 to 3 carbon atoms and 0 to 2 heteroatoms, (iii) an aliphatic moiety with a main chain of 3 to 80 carbon atoms and 0 to about 30, and a C&#x2261;C group or an azido group.

Amphiphilic polymers and nanocrystals coated therewith

Growing community of inventors

Singapore, Singapore

Dominik Janczewski