Dsm IP Assets B.v.

Dominik Imfeld

Hugo Ziegler

Marc Heidl

Martin Stöckli

Peter Wikstroem

Eileen Jackson

Dirk Weber

Jürgen H Vollhardt

Remo Campiche

Eliane Ursula Wandeler

Marie-Sophie Meisinger

Guillaume Bernard Laurent

Mathias Gempeler

Dominique Crestia

Rainer Voegeli

Rolf Schuetz

Alexandre Rio

François Paul

Christophe Boissard

Regina Goralczyk

Alexander Radspieler

Remo Gräub

Anthony Rawlings

Kerstin Katharina Schenk

The present invention relates to a blend comprising palmitoyl tripeptide-5, an algae extract, panthenol, water and optionally pullulan and/or sodium hyaluronate.

Premixed blend comprising tripeptide and algae extract

The present invention relates to gentiopicroside freeand/orextracts. Furthermore, it relates to cosmetic compositions comprising such gentiopicroside freeorextract, as well as mixtures thereof.

Gentiopicroside free gentiana extract

The present invention relates to a novel use of proline containing dipeptides for the prevention and/or treatment of skin conditions associated with altered, damaged or malfunctioning sebaceous glands.

Method for the treatment of skin disorders using dipeptide diaminobutyroyl benzylamide diacetate

Proline containing dipeptides are disclosed for up-regulating of genes involved in collagen fiber maturation and thus for revitalizing, strengthening and increasing the integrity of collagen fibers. These proline containing dipeptides are furthermore particularly suitable for improving the skin firmness, texture and elasticity as well as reducing the pore size and increasing skin moisturization.

Use of proline containing dipeptides

Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which Ris H, C-C-alkyl, cycloalkyl or aryl-C-C-alkyl, n is 1-4, X is &#x2014;O&#x2014;, &#x2014;NH&#x2014; or &#x2014;NR&#x2014; and RH or C-C-alkyl; and at least one compound corresponding to the above formula (I) but in which XRwith X having the possible meaning of &#x2014;NH&#x2014; is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is &#x2014;NR&#x2014; and both Rand Rare different from H, and the compounds corresponding to formula (I) but in which XRwith X having the possible meaning of &#x2014;NH&#x2014; is the residue of an alpha-amino acid, as such.

Cosmetic composition for stimulating the synthesis of proteins of the basement membrane

The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: Rrepresents H, &#x2014;C(O)&#x2014;R, &#x2014;SO&#x2014;Ror &#x2014;C(O)&#x2014;XR; Rand R, independent of one another, represent (CH)&#x2014;NHor (CH)&#x2014;NHC(NH)NH; n equals 1 4; Rrepresents linear or branched C-Calkyl that is optionally substituted by hydroxy; Rand R, independent of one another, represent hydrogen, optionally substituted (C-C)alkyl, optionally substituted C-Calkenyl, optionally substituted phenyl, optionally substituted phenyl-C-Calkyl or 9-fluorenyl-methyl; X represents oxygen (&#x2014;O&#x2014;) or NH&#x2014;; or XRwith X&#x2550;O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that Rand Rdo not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).

Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure

Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which Ris H, C-C-alkyl, cycloalkyl or aryl-C-C-alkyl, n is 1-4, X is &#x2014;O&#x2014;, &#x2014;NH&#x2014; or &#x2014;NR&#x2014; and RH or C-C-alkyl; and at least one compound corresponding to the above formula (I) but in which XRwith X having the possible meaning of &#x2014;NH&#x2014; is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is &#x2014;NR&#x2014; and both Rand Rare different from H, and the compounds corresponding to formula (I) but in which XRwith X having the possible meaning of &#x2014;NH&#x2014; is the residue of an alpha-amino acid, as such. 

The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: Rrepresents H, &#x2014;C(O)&#x2014;R, &#x2014;SO&#x2014;Ror &#x2014;C(O)&#x2014;XR; Rand R, independent of one another, represent (CH)&#x2014;NHor (CH)&#x2014;NHC(NH)NH; n equals 1 4; Rrepresents linear or branched C-Calkyl that is optionally substituted by hydroxy; Rand R, independent of one another, represent hydrogen, optionally substituted (C-C) alkyl, optionally substituted C-Calkenyl, optionally substituted phenyl, optionally substituted phenyl-C-Calkyl or 9-fluorenyl-methyl; X represents oxygen (&#x2014;O&#x2014;) or &#x2014;NH&#x2014;; or XRwith X&#x2550;O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that Rand Rdo not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I). 

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Kaiseraugst, Switzerland

Dominik Imfeld