National Institutes of Health, a Component of the US Dept. of Health & Human Services

Provid Pharmaceuticals Inc.

Max-delbruck-centrum Fur Molekulare Medizin in Der Helmholtz-gemeinschaft

Dominic Scudiero

Yves Pommier

Robert H Shoemaker

Michael Currens

John Cardellina

Christopher Self

Guangtao Zhang

George Lountos

Andrew Jobson

Charles Michael Cook

Ulrike Sack

David Waugh

Andrew Vargha Colasanti

Sudhir Kondapaka

Andy Jobson

Andrew Colasanti

Charles M Cook

John Cardelina

Robert Shoemaker

Christopher R Self

A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Gis a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted. 

Method of treating HCV infection with a small molecule CHK2 inhibitor

Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.

Use of Chk2 kinase inhibitors for cancer treatment

Provided herein are Compounds having the following structure: 

Kinase inhibitors, compositions thereof, and methods of use therewith

Growing community of inventors

Frederick, MD, United States of America

Dominic Scudiero