Millennium Pharmaceuticals Limited

Ore Pharmaceuticals Inc.

Dominic Picarella

Walter Newman

Douglas J Ringler

Louis Anthony Tartaglia

David W White

Thomas M Barnes

Michael J Briskin

Robert Coopersmith

Scott Edward Malstrom

Dulce Soler

Thomas Michael Barnes

Robert Mark Coopersmith

David William White

A method for treating an inflammatory disease of the digestive tract, for example inflammatory bowel disease, in a subject comprises administering to the subject a therapeutically effective amount of a compound selected from the group consisting of (S,S)-2- [1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]-ethylamino]-4-methylpentanoic acid and pharmaceutically acceptable salts thereof.

Method for treating inflammatory diseases of the digestive tract

The present invention relates to fusion proteins comprising a naturally occurring primate MAdCAM, wherein said naturally occurring primate MAdCAM binds &#x3b1;4&#x3b2;7 integrin and has at least about 75% amino acid similarity to an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4 and SEQ ID NO:6.

Mucosal vascular addressing and uses thereof

Biotinylated pharmacologically active agents and complexes containing same are disclosed. In particular, biotinylated-chemokines are described. The complexes further include an anti-biotin antibody that selectively binds to biotin. The complex can be dissociated by contact with free biotin. The complexes are particularly useful for enhancing an immune response to tumor cells and virus-infected cells, in vivo or in vitro.

Biotinylated-chemokine antibody complexes

The invention relates to the treatment of individuals suffering from a disease associated with leukocyte recruitment to the gastrointestinal tract or other tissues as a result of binding of leukocytes to gut-associated endothelium expressing the molecule MAdCAM (such as inflammatory bowel disease), comprising administering to the individual an effective amount of an antibody which inhibits the binding of leukocytes to endothelial MAdCAM.

Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through &agr; 4 &bgr; 7 and its ligands and madcam

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Sudbury, MA, United States of America

Dominic Picarella