Idexx Laboratories, Inc.

Vue Tek Scientific, LLC

Dominic Pelletier

Jeremy Hammond

Jason Aguiar

Robert W Lachapelle

Murthy V S N Yerramilli

Milton Waner

Louis M Fink

Mark R Arsenault

Chandler G Sinnett

Walter Hebold

Jeffrey Eric Phelps

Evan M Peck

William J Traigle

Ronald Marcotte

Pamela Ann Cacavas

Wendy O'Malley LePage

Eric Allen Steva

Jesse Daniel Faller

Lucius S Fox

Jeffrey Phelps

An insert mounted in a mixing cup and used by an automated chemical analyzer for removing a targeted component of a liquid sample includes a porous matrix formed of or carrying in an immobilized state functionalized particles having properties such that the targeted component of the liquid sample adheres to the functionalized particles. When the liquid sample is expelled from a disposable tip fitted on the end of a pipette forming part of the automated chemical analyzer into the mixing cup, the liquid sample is drawn into the matrix of the insert by capillary action, whereupon the targeted component of the liquid sample adheres to the immobilized functionalized particles of the matrix.

Matrix and associated sample or mixing cup used for removing components of a liquid sample

A method using a chemical analyzer for removing a component of a liquid sample which may interfere with a test performed on a test assay includes the steps of adding the liquid sample to a sample cup, transferring a volume of the liquid sample to a mixing cup containing an IMAC (Immobilized Metal Affinity Chromatography) resin containing porous beads to form a sample/resin solution in the mixing cup, using a pipette of the chemical analyzer to repeatedly aspirate the sample/resin solution into a disposable pipette tip of the pipette and expelling the sample/resin solution from the pipette tip into the mixing cup to achieve a mixed sample/resin solution in the mixing cup, and allowing the mixed sample/resin solution in the mixing cup to rest undisturbed so that the interfering component of the liquid sample adheres to the porous beads and the beads settle to a bottom portion of the mixing cup, resulting in a refined liquid sample devoid of the interfering component and occupying an upper portion of the mixing cup for later dispensing on the test assay.

Method for removing interfering components of a liquid sample prior to dispensing same on a chemical reagent test slide

An automated method for calibrating in real time a diagnostic analyzer includes the steps of receiving diagnostic results of patient samples calculated by the analyzer using pre-set parameters of the analyzer, and calculating the centroid of the analyzer's diagnostic results. The centroid of the analyzer's diagnostic results is subtracted from a centroid of diagnostic results of a field population of comparable analyzers to obtain a bias in the centroid of the analyzer's diagnostic results. The bias is compared to predetermined limits. Should the bias fall outside the predetermined limits, an optimization factor is derived and applied to the analyzer's diagnostic results to obtain optimized results from the analyzer without changing the pre-set parameters of the analyzer.

Automated calibration method and system for a diagnostic analyzer

A pipette tip includes a main body having an upper end, a lower end and a sidewall extending between the two ends. A bore extends axially through the main body between the upper and lower ends. The lower end has a bottom surface in which is formed a central opening that communicates with the axial bore to allow the passage of fluid therethrough. The bottom surface is formed with at least one groove that may be concentrically disposed or spirally disposed about the central opening. The at least one groove acts to inhibit fluid passing through the central opening from at least partially flowing along the outer surface of the sidewall from the central opening toward the upper end of the main body of the pipette tip.

Pipette tip

An imaging system for locating subcutaneous blood vessels and a method for locating subcutaneous blood vessels using the system. The system includes at least one infrared emitter an infrared detector, a computing unit that enhances images and outputs enhanced images in substantially real time, a display device for displaying enhanced images, and a power source. The method includes the steps of preparing a body target area, putting on the headset, powering up the system, locating a target blood vessel, inserting a needle into the target blood vessel, and performing the medical procedure.

System and method for locating and accessing a blood vessel

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Raymond, ME, United States of America

Dominic Pelletier