Genmark Diagnostics, Inc.

Other

Advanced Liquid Logic, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Dominic Aiello

David W Wright

Brian P Murphy

Jon Faiz Kayyem

Scott Corey

Eric D Schneider

George Maltezos

Sean Ford

Darren S Gray

Robert Clark

Peter Kroehl

Jay Srinivasan

Andrew Fish

Vamsee K Pamula

Vijay Srinivasan

Tyler David Jensen

Jacob S Semons

Mark S Semons

Bradford Frederick Tieman

David Walter Wright

Darren Scott Gray

Brian Murphy

In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.

Processing cartridge and method for detecting a pathogen in a sample

An apparatus configured for displacing fluid from a fluid container comprises first and second actuators configured to be movable together until the first actuator compresses a first part of the fluid container and then moveable independently until the second actuator compresses a second part of the fluid container. Fluid containers comprise a first vessel, a second vessel, and a sealing partition preventing fluid flow from the second vessel and further include a piercing point for piercing the sealing partition to permit fluid flow from the second vessel. A fluid container comprises a vessel configured to be collapsed to displace fluid from the vessel, a housing surrounding at least a portion of the vessel, and a floating compression plate movably disposed within the housing and configured to permit an external actuator to press the compression plate into the vessel to collapse the vessel and displace the fluid contents therefrom.

Apparatus, devices, and methods for manipulating deformable fluid vessels

Biochip cartridge

A fly-fishing reel comprised of a spool assembly, frame assembly, and drag knob assembly, wherein the drag knob assembly may be removed without the use of tools in order to access the drag components and is attached without the use of fasteners. Drag components are contained between the frame and drag knob assemblies and are accessed by removing the drag knob assembly via a channel locking system. Accessing the drag components allows the user to switch the direction of retrieve and allows a secondary means of altering the range and characteristics of the drag settings. The drag system is sealed via two points on each open end of the drag housing portion of the frame, allowing for minimal maintenance and increased reliability of the drag system.

Fly reel with tool free channel locking drag system

An apparatus for processing a fluid module, including a collapsible vessel supported on a planar substrate, comprises a first actuator component configured to be movable in a first direction is generally parallel to the plane of the substrate, a second actuator component configured to be movable in a second direction having a component that is normal to the plane of the substrate, and a motion conversion mechanism coupling the first actuator component with the second actuator component and configured to convert movement of the first actuator component in the first direction into movement of the second actuator component in the second direction.

Apparatus and methods for manipulating deformable fluid vessels

Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation

Cartridge for performing assays in a closed sample preparation and reaction system

Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system

An apparatus configured for displacing fluid from a fluid container comprises first and second actuators configured to be movable together until the first actuator compresses a first part of the fluid container and then moveable independently until the second actuator compresses a second part of the fluid container. Fluid containers comprise a first vessel, a second vessel, and a sealing partition preventing fluid flow from the second vessel and further include piercing means for piercing the sealing partition to permit fluid flow from the second vessel. A fluid container comprises a vessel configured to be collapsed to displace fluid from the vessel, a housing surrounding at least a portion of the vessel, and a floating compression plate movably disposed within the housing and configured to permit an external actuator to press the compression plate into the vessel to collapse the vessel and displace the fluid contents therefrom.

A fluid container comprises a first vessel, a second vessel connected or connectable to the first vessel, and a sealing partition preventing fluid flow from the second vessel. The container further includes a spherical opening element initially supported within the second vessel by the sealing partition and configured to be contacted with the sealing partition to open the sealing partition and permit fluid flow from the second vessel.

Devices and methods for manipulating deformable fluid vessels

Growing community of inventors

Denver, CO, United States of America

Dominic Aiello