Farmitalia Carlo Erba S.r.l.

Pharmacia & Upjohn S.p.a.

Domenico Trizio

Gianfederico Doria

Mario Ferrari

Anna Maria Isetta

Maria C Fornasiero

Rinaldo Ferreccio

Elena Barbanti

Marcellino Tibolla

Fabrizio Marcucci

Marta Ghislieri

MariaChiara Fornasiero

AnnaMaria Isetta

Pyrrolydenemethyl-derivatives and process for their preparation

A monoclonal antibody is provided which is able to neutralize both human TNF .alpha. and TNF .beta., or a binding fragment thereof. A stable hybridoma cell line and progeny thereof are also provided which secrete such a monoclonal antibody. The monoclonal antibody or a fragment thereof may be used to detect the content of human TNF in a sample of body fluid.

Monoclonal antibodies against human Tumor Necrosis Factor .alpha.

Condensed pyrazole 3-oxo-propanenitrile derivatives

This invention relates to a method of treating rheumatoid arthritis, which method comprises administering to a mammal a therapeutically effective amount of a compound of formula (I): ##STR1## wherein R1 is unsubstituted or substituted phenyl;

Morphalinomethyl-substituted 1-phenyl-indero-[1,2-c]pyrazol-3-yl

Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents an oxygen atom or a --CH(R.sub.4)--, --O--CH(R.sub.4)--, --S(O).sub.n --CH(R.sub.4)--, --CH(R.sub.4)--O--, --CH(R.sub.4)--S(O).sub.n -- or --CH(R.sub.4)--CH.sub.2 -- group wherein n is 0, 1 or 2; R.sub.1 represents C.sub.1 -C.sub.6 alkyl, pyridyl or unsubstituted or substituted phenyl; R.sub.2, R.sub.3, and R.sub.4 are as herein defined; and Q is hydrogen, carboxy, C.sub.2 -C.sub.7 -alkoxycarbonyl or a --CON(R.sub.a)R.sub.b group, R.sub.a and R.sub.b being as defined herein; and their pharmaceutically acceptable salts are useful in the preparation of pharmaceutical compositions active in the treatment of autoimmune diseases.

Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the

Use of heteroaryl-3-oxo-propanenitrile derivatives in treating clinical

Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents an oxygen atom or a --CH(R.sub.4)--, --O--CH(R.sub.4)--, --S(O).sub.n --CH(R.sub.4)--, --CH(R.sub.4)--O--, --CH(R.sub.4)--S(O).sub.n -- --CH(R.sub.4)--CH.sub.2 -- group wherein n is 0, 1 or 2; R.sub.1 represents C.sub.1 -C.sub.6 alkyl, pyridyl or unsubstituted or substituted phenyl; R.sub.2, R.sub.3, and R.sub.4 are as herein defined; and Q is hydrogen, carboxy, C.sub.2 -C.sub.7 -alkoxycarbonyl or a --CON(R.sub.a)R.sub.b group, R.sub.a and R.sub.b being as defined herein; and their pharmaceutically acceptable salts are useful in the preparation of pharmaceutical compositions active in the treatment of autoimmune diseases.

Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of

Tricyclic 3-oxo-propanenitrile derivatives

The invention relates to compounds having the general formula (I) ##STR1## and the pharmaceutically acceptable salts thereof, which possess immunomodulating activity and are useful e.g. in the treatment of neoplastic diseases and acute and chronic infections of both bacterial and viral origin in mammals.

Condensed pyrazole derivatives, pharmaceutical compositions and use

The invention relates to compounds having the general formula (I) ##STR1## wherein n is zero, 1 or 2;

Cinnoline-carboxamides and process for their preparation

Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions

Growing community of inventors

Cassina Rizzardi, Italy

Domenico Trizio